CAS 122320-73-4
:Rosiglitazone
Description:
Rosiglitazone is an antidiabetic medication primarily used to treat type 2 diabetes mellitus. It belongs to the thiazolidinedione class of drugs, which function as agonists of the peroxisome proliferator-activated receptor gamma (PPAR-γ). This mechanism enhances insulin sensitivity in peripheral tissues, thereby improving glucose uptake and utilization. Rosiglitazone is typically administered orally and is often prescribed in conjunction with other antidiabetic agents. The substance is characterized by its molecular formula, which includes carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its complex structure. It is known for its potential side effects, including weight gain and an increased risk of cardiovascular events, which have led to scrutiny and regulatory changes regarding its use. The drug's pharmacokinetics involve extensive hepatic metabolism, primarily through cytochrome P450 enzymes, and it has a relatively long half-life, allowing for once-daily dosing. Due to its specific action on insulin sensitivity, Rosiglitazone plays a significant role in the management of blood glucose levels in diabetic patients.
Formula:C18H20ClN3O3S
InChI:InChI=1/C18H19N3O3S.ClH/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;/h2-9,15H,10-12H2,1H3,(H,20,22,23);1H
InChI key:InChIKey=YASAKCUCGLMORW-UHFFFAOYSA-N
SMILES:C(C1SC(=O)NC1=O)C2=CC=C(OCCN(C)C3=CC=CC=N3)C=C2
Synonyms:- 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione (2Z)-but-2-enedioate
- 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione hydrochloride
- 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
- 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]-phenyl]methyl]-2,4-thiazolidine-dione
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Found 11 products.
Rosiglitazone
CAS:Formula:C18H19N3O3SPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:357.43Rosiglitazone Maleate
CAS:<p>Compounds containing an unfused thiazole ring (whether</p>Formula:C18H19N3O3S·C4H4O4Color and Shape:White Off-White SolidMolecular weight:357.114715-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS:Formula:C18H19N3O3SPurity:98%Color and Shape:SolidMolecular weight:357.4268Rosiglitazone
CAS:Formula:C18H19N3O3SPurity:≥ 99.0% (dried basis)Color and Shape:White powderMolecular weight:357.43Rosiglitazone
CAS:<p>Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.</p>Formula:C18H19N3O3SPurity:98.61% - 99.87%Color and Shape:White To Off-White Crystalline PowderMolecular weight:357.43Rosiglitazone base
CAS:<p>PPAR-γ agonist; anti-diabetic; anti-inflammatory</p>Formula:C18H19N3O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:357.43 g/mol5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione
CAS:Formula:C18H19N3O3SPurity:98%Color and Shape:SolidMolecular weight:357.43Rosiglitazone - Bio-X ™
CAS:<p>Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is used as an adjunct to diet and exercise to maintain glycaemic control in type 2 diabetes. This drug acts as a selective agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of these receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization.</p>Formula:C18H19N3O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:357.43 g/mol
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