CAS: 1223403-58-4 - LOXO-101

Formula: C₂₁H₂₂F₂N₆O₂

InChI: InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1

InChI key: InChIKey=NYNZQNWKBKUAII-KBXCAEBGSA-N

SMILES: O=C(NC=1C=NN2C=CC(=NC12)N3CCCC3C4=CC(F)=CC=C4F)N5CCC(O)C5

Synonyms:

• (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide
• (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
• 1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-
• Arry-470
• Larotrectinib

1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-

CAS: 1223403-58-4

• Formula: C₂₁H₂₂F₂N₆O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 428.4352

Larotrectinib

CAS: 1223403-58-41223405-08-0

• Formula: C₂₁H₂₂F₂N₆O₂
• Color and Shape: Brown Solid
• Molecular weight: 428.44

Larotrectinib-d4

CAS: 1223403-58-42365076-54-4

• Formula: C₂₁H₁₈D₄F₂N₆O₂
• Molecular weight: 432.47

Larotrectinib

CAS: 1223403-58-4

Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective …

• Formula: C₂₁H₂₂F₂N₆O₂
• Purity: 100%
• Color and Shape: Solid
• Molecular weight: 428.44

Larotrectinib-d7

CAS: 1223403-58-4

• Formula: C₂₁H₁₅D₇F₂N₆O₂
• Molecular weight: 435.49

Larotrectinib Sulfate

CAS: 1223403-58-41223405-08-0

Applications Larotrectinib Sulfate is a potent and selective oral ATP-competitive inhibitor of tropomyosin receptor kinases …

• Formula: C₂₁H₂₂F₂N₆O₂H₂O₄S)
• Color and Shape: Light Orange to Light Brown Solid
• Molecular weight: 428.44 + (98.08)

Larotrectinib

CAS: 1223403-58-4

A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor …

• Formula: C₂₁H₂₂F₂N₆O₂
• Purity: Min. 98 Area-%
• Color and Shape: Yellow Powder
• Molecular weight: 428.44 g/mol