CAS 1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide

Description:

The chemical substance with the name "(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide" and CAS number "1223403-58-4" is characterized by its complex molecular structure, which includes multiple functional groups and stereocenters. This compound features a pyrrolidine backbone, which contributes to its potential biological activity. The presence of a difluorophenyl group suggests that it may exhibit unique electronic properties, potentially influencing its interaction with biological targets. The pyrazolo[1,5-a]pyrimidine moiety is indicative of its possible role in medicinal chemistry, particularly in the development of pharmaceuticals. The hydroxyl and carboxamide functional groups may enhance solubility and bioavailability, making it a candidate for therapeutic applications. Overall, this compound's intricate structure and functional diversity suggest it may have significant implications in drug discovery and development, particularly in areas related to neurological or oncological research. Further studies would be necessary to elucidate its specific biological activities and mechanisms of action.

Formula: C₂₁H₂₂F₂N₆O₂

InChI: InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1

InChI key: InChIKey=NYNZQNWKBKUAII-KBXCAEBGSA-N

SMILES: FC1=C([C@@H]2N(CCC2)C3=NC4=C(NC(=O)N5CC[C@H](O)C5)C=NN4C=C3)C=C(F)C=C1

Synonyms:

• (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide
• (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
• 1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-
• Arry-470
• Larotrectinib
• LOXO 101

1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-

CAS: 1223403-58-4

Formula: C₂₁H₂₂F₂N₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 428.4352

Ref: IN-DA00174H

Larotrectinib

CAS: 1223403-58-4

Larotrectinib

Purity: ≥98%

Molecular weight: 428.44g/mol

Ref: 54-BUP08919

Larotrectinib

CAS: 1223403-58-4

Formula: C₂₁H₂₂F₂N₆O₂

Color and Shape: Brown Solid

Molecular weight: 428.44

Ref: 4Z-L-160001

LarotrectinibFor

CAS: 1223403-58-4

LarotrectinibFor

Purity: 99%

Molecular weight: 428.43g/mol

Ref: 54-PC108871

Larotrectinib

CAS: 1223403-58-4

Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).

Formula: C₂₁H₂₂F₂N₆O₂

Purity: 99.15% - >99.99%

Color and Shape: Solid

Molecular weight: 428.44

Ref: TM-T5995

Larotrectinib-d7

CAS: 1223403-58-4

Formula: C₂₁H₁₅D₇F₂N₆O₂

Molecular weight: 435.49

Ref: 4Z-L-160003

Larotrectinib

CAS: 1223403-58-4

Purity: 97%

Molecular weight: 428.444000244141

Ref: 10-F861810

Larotrectinib

CAS: 1223403-58-4

A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.

Formula: C₂₁H₂₂F₂N₆O₂

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 428.44 g/mol

Ref: 3D-FD145150