CAS 122341-38-2

mTHPC

Description:

mTHPC, or meta-tetrahydroxyphenylchlorin, is a chlorin derivative that is primarily used in photodynamic therapy (PDT) for cancer treatment. It exhibits a strong absorption in the red region of the spectrum, which is advantageous for therapeutic applications as it allows for deeper tissue penetration. mTHPC is characterized by its ability to generate reactive oxygen species upon light activation, leading to localized cell damage and tumor destruction. The compound is known for its high phototoxicity, which is effective against various types of cancer cells while minimizing damage to surrounding healthy tissues. Additionally, mTHPC has a relatively high lipophilicity, which influences its distribution and accumulation in tumor tissues. Its pharmacokinetics can be affected by factors such as formulation and administration route. Safety profiles indicate that while mTHPC can cause skin photosensitivity, its therapeutic benefits in oncology make it a valuable agent in the field of cancer treatment. Overall, mTHPC represents a significant advancement in targeted cancer therapies utilizing light-activated mechanisms.

Formula: C₄₄H₃₂N₄O₄

InChI: InChI=1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2/b41-33-,41-34?,42-35?,42-37-,43-36?,43-38-,44-39-,44-40?

InChI key: InChIKey=LYPFDBRUNKHDGX-SOGSVHMOSA-N

SMILES: OC=1C=C(C=2C=3NC(=CC3)C(=C4N=C(C=C4)C(=C5NC(=C(C6=NC2CC6)C7=CC(O)=CC=C7)C=C5)C8=CC(O)=CC=C8)C9=CC(O)=CC=C9)C=CC1

Synonyms:

• 3,3',3'',3'''-(2,3-Dihydroporphyrin-5,10,15,20-Tetrayl)Tetraphenol
• 3,3',3',3''-(7,8-Dihydroporphyrin-5,10,15,20-Tetrayl)Tetraphenol
• 3,3′,3′′,3′′′-(7,8-Dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[phenol]
• 3,3′,3′′,3′′′-(7,8-Dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol
• 5,10,15,20-Tetra(M-Hydroxyphenyl)Chlorin
• 5,10,15,20-Tetrakis(m-hydroxyphenyl)chlorin
• 8-Dihydroporphyrin-5
• Foscan
• Fosgel
• Foslip
• Foslipos
• Fospeg
• Phenol, 3,3′,3′′,3′′′-(7,8-dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-
• Sml 1707
• m-Tetrahydroxyphenylchlorin
• mTHPC

Phenol, 3,3',3'',3'''-(7,8-dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-

CAS: 122341-38-2

Formula: C₄₄H₃₂N₄O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 680.7493

Ref: IN-DA00174L

Temoporfin

CAS: 122341-38-2

Temoporfin

Purity: ≥98%

Molecular weight: 680.75g/mol

Ref: 54-BUP05345

Temoporfin

CAS: 122341-38-2

Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck.

Formula: C₄₄H₃₂N₄O₄

Purity: 99.71%

Color and Shape: Solid

Molecular weight: 680.75

Ref: TM-T17035

Temoporfin

CAS: 122341-38-2

Temoporfin is a photosensitizer, which is a compound used in photodynamic therapy (PDT). It is derived from chlorin, a naturally occurring macrocycle related to porphyrin. The mode of action involves the administration of Temoporfin, followed by its selective accumulation in cancerous tissues. Once accumulated, the target area is exposed to a specific wavelength of light, activating the Temoporfin. This activation leads to the production of reactive oxygen species, inducing cell death through apoptosis or necrosis.Temoporfin is primarily used in the treatment of various cancers, notably head and neck squamous cell carcinomas. Its ability to provide a targeted therapeutic effect while minimizing damage to surrounding healthy tissues makes it a significant tool in oncological treatments. The specificity and efficacy of Temoporfin in PDT highlight its importance as a minimally invasive therapeutic option within clinical settings. Continued research and development in its application are likely to expand its use to other types of malignancies and enhance patient outcomes.

Formula: C₄₄H₃₂N₄O₄

Purity: Min. 95%

Molecular weight: 680.75 g/mol

Ref: 3D-XEA34138

Temoporfin, ~ 90%

Controlled Product

CAS: 122341-38-2

Applications Temoporfin is a synthetic chlorin with light-activated actions. It accumulates in tumor cells and through light activation and oxygen radical formation, it leads to necrosis and cell death.
References Alian, W. et al.: Br. J. Cancer, 70, 880 (1994); Ris, H. et al.: Br. J. Cancer., 64, 1116 (1991);

Formula: C₄₄H₃₂N₄O₄

Purity: ~90%

Color and Shape: Purple

Molecular weight: 680.75

Ref: TR-T017350