CAS 122341-38-2: mTHPC

Description: mTHPC, or meta-tetrahydroxyphenylchlorin, is a chlorin derivative that is primarily used in photodynamic therapy (PDT) for cancer treatment. It exhibits a strong absorption in the red region of the spectrum, which is advantageous for therapeutic applications as it allows for deeper tissue penetration. mTHPC is characterized by its ability to generate reactive oxygen species upon light activation, leading to localized cell damage and tumor destruction. The compound is known for its high phototoxicity, which is effective against various types of cancer cells while minimizing damage to surrounding healthy tissues. Additionally, mTHPC has a relatively high lipophilicity, which influences its distribution and accumulation in tumor tissues. Its pharmacokinetics can be affected by factors such as formulation and administration route. Safety profiles indicate that while mTHPC can cause skin photosensitivity, its therapeutic benefits in oncology make it a valuable agent in the field of cancer treatment. Overall, mTHPC represents a significant advancement in targeted cancer therapies utilizing light-activated mechanisms.

Formula: C₄₄H₃₂N₄O₄

InChI: InChI=1S/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2/b41-33-,41-34?,42-35?,42-37-,43-36?,43-38-,44-39-,44-40?

InChI key: InChIKey=LYPFDBRUNKHDGX-SOGSVHMOSA-N

SMILES: OC1=CC=CC(=C1)C2=C3N=C(C=C3)C(C=4C=CC=C(O)C4)=C5C=CC(N5)=C(C=6C=CC=C(O)C6)C7=NC(=C(C=8C=CC=C(O)C8)C9=CC=C2N9)CC7

Synonyms:

• 3,3',3'',3'''-(2,3-Dihydroporphyrin-5,10,15,20-Tetrayl)Tetraphenol
• 3,3',3',3''-(7,8-Dihydroporphyrin-5,10,15,20-Tetrayl)Tetraphenol
• 3,3′,3′′,3′′′-(7,8-Dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[phenol]
• 3,3′,3′′,3′′′-(7,8-Dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol
• 5,10,15,20-Tetra(M-Hydroxyphenyl)Chlorin
• 5,10,15,20-Tetrakis(m-hydroxyphenyl)chlorin
• 8-Dihydroporphyrin-5
• Foscan
• Fosgel
• Foslip
• Foslipos
• Fospeg
• Phenol, 3,3′,3′′,3′′′-(7,8-dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-
• Sml 1707
• m-Tetrahydroxyphenylchlorin
• mTHPC
• Temoporfin

Phenol, 3,3',3'',3'''-(7,8-dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-

CAS: 122341-38-2

• Formula: C₄₄H₃₂N₄O₄
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 680.7493

Temoporfin

CAS: 122341-38-2

• Purity: 99.7%
• Molecular weight: 680.75g/mol

Temoporfin

CAS: 122341-38-2

Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head …

• Formula: C₄₄H₃₂N₄O₄
• Purity: 99.71%
• Color and Shape: Solid
• Molecular weight: 680.75

Temoporfin, ~ 90%

CAS: 122341-38-2

Applications Temoporfin is a synthetic chlorin with light-activated actions. It accumulates in tumor cells and …

• Formula: C₄₄H₃₂N₄O₄
• Purity: ~90%
• Color and Shape: Purple
• Molecular weight: 680.75

Temoporfin

CAS: 122341-38-2

Temoporfin is a photodynamic agent that is activated by light of wavelengths from 630-680 nm. …

• Formula: C₄₄H₃₂N₄O₄
• Purity: Min. 95%
• Molecular weight: 680.75 g/mol