CAS 122384-88-7

diabetes-associated peptide amide human

Description:

Diabetes-associated peptide amide human, also known by its CAS number 122384-88-7, is a peptide that plays a role in the regulation of glucose metabolism and insulin secretion. This peptide is derived from the proinsulin molecule and is associated with the physiological processes related to diabetes. Its structure typically consists of a sequence of amino acids that contribute to its biological activity, influencing various metabolic pathways. The peptide is often studied for its potential implications in diabetes research, particularly in understanding the mechanisms of insulin resistance and secretion. In terms of solubility, it is generally soluble in aqueous solutions, which is typical for peptides. The stability of this peptide can be affected by factors such as pH and temperature, which are crucial for its storage and handling in laboratory settings. Overall, diabetes-associated peptide amide human is significant in the context of metabolic disorders, and ongoing research continues to explore its therapeutic potential and mechanisms of action in diabetes management.

Formula: C₁₆₅H₂₆₁N₅₁O₅₅S₂

InChI: InChI=1/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179)/t75-,76-,77-,78-,79-,80+,81+,82+,83+,84+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-,127-,128-,129-/m0/s1

Synonyms:

• Amylin (human)
• H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bond)

Amylin (human)

CAS: 122384-88-7

The amyloidogenic peptide hormone amylin 1-37 (or Islet Amyloid Polypeptide, IAPP), KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY amide, has been isolated from the amyloid-rich pancreases of diabetic patients. hIAPP forms fibrillar peptide deposits in the pancreatic islets of Langerhans, which may be related to death of the insulin-producing islet β-cells in type 2 diabetes mellitus.

Formula: C₁₆₅H₂₆₁N₅₁O₅₅S₂

Purity: 95.1%

Color and Shape: White

Molecular weight: 3903.33

Ref: 01-4030200

Amylin, amide, human

CAS: 122384-88-7

Amylin, amide, human(DAP Amide) is a 37-amino acid peptide hormone co-secreted with insulin to regulate postprandial glucose levels.

Formula: C₁₆₅H₂₆₁N₅₁O₅₅S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 3903.28

Ref: TM-TP1183

Amylin, human amidated

CAS: 122384-88-7

Formula: C₆₇H₉₆N₁₉O₁₉

Purity: 97%

Molecular weight: 1471.5950

Ref: IN-DA00176K

Amylin (human)

CAS: 122384-88-7

Amylin (human)

Ref: 54-BIBA1029

Amylin (Human)

CAS: 122384-88-7

Amylin is a peptide hormone that is found in the pancreas. It regulates blood glucose levels and plays an important role in diabetes. Amylin is also used as a research tool for studying the function of ion channels, cell biology, protein interactions, and pharmacology.

Formula: C₁₆₅H₂₆₁N₅₁O₅₅S₂

Purity: Min. 95%

Molecular weight: 3,903.3 g/mol

Ref: 3D-PAM-4219-V

Amylin (human) trifluoroacetate salt

CAS: 122384-88-7

Amylin is a hormone that regulates the release of insulin from the pancreas. Amylin is a protein that consists of 39 amino acids, and in its natural form it is not soluble in water. The amyloid fibrils are insoluble aggregates of proteins that can be found in the brain tissue of patients with Alzheimer's disease. Amylin has been shown to have an entrapment efficiency greater than 96% by using polymeric particles with a diameter less than 50 microns. These particles are able to increase water solubility and nutrient metabolism, as well as improve evaporation rates. They also provide an increased surface area for absorption and pharmacological properties. Amylin has been shown to lower postprandial glycemia when used with insulin in type II diabetes mellitus patients, and may also be an anorectic agent.

Formula: C₁₆₅H₂₆₁N₅₁O₅₅S₂

Purity: Min. 95%

Molecular weight: 3,903.28 g/mol

Ref: 3D-FA110263