CAS 122406-02-4

2′,3′-Dideoxyinosine 5′-(tetrahydrogen triphosphate)

Description:

2′,3′-Dideoxyinosine 5′-(tetrahydrogen triphosphate), commonly referred to as ddITP, is a nucleotide analog that plays a significant role in molecular biology and biochemistry, particularly in the study of nucleic acid synthesis and antiviral research. This compound is characterized by the absence of hydroxyl groups at the 2' and 3' positions of the ribose sugar, which imparts unique properties that inhibit DNA polymerase activity, making it a valuable tool in the development of antiviral therapies, especially against HIV. The presence of the triphosphate group enhances its reactivity and allows it to participate in biochemical reactions similar to natural nucleotides. ddITP can be incorporated into DNA strands during replication, leading to chain termination, which is a critical mechanism for its antiviral action. Its CAS number, 122406-02-4, is a unique identifier that facilitates the cataloging and research of this compound in scientific literature and databases. Overall, ddITP is an important compound in the field of nucleic acid research and therapeutic development.

Formula: C₁₀H₁₅N₄O₁₂P₃

InChI: InChI=1S/C10H15N4O12P3/c15-10-8-9(11-4-12-10)14(5-13-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H,11,12,15)(H2,16,17,18)/t6-,7+/m0/s1

InChI key: InChIKey=ZXZIQGYRHQJWSY-NKWVEPMBSA-N

SMILES: O=C1C2=C(N(C=N2)[C@@H]3O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)CC3)NC=N1

Synonyms:

• 2′,3′-Dideoxy-ITP
• 2′,3′-Dideoxyinosine 5′-(tetrahydrogen triphosphate)
• 2′,3′-Dideoxyinosine 5′-triphosphate
• 2′,3′-Dideoxyinosine triphosphate
• DDITP compound
• Inosine 5′-(tetrahydrogen triphosphate), 2′,3′-dideoxy-
• Inosine, 5'-(tetrahydrogen triphosphate), 2',3'-dideoxy-
• triphosphoric acid, mono[[(2S,5R)-5-(3,6-dihydro-6-oxo-9H-purin-9-yl)tetrahydro-2-furanyl]methyl] ester
• 2',3'-Dideoxyribosylinosine 5'-triphosphate

2',3'-Dideoxyinosine 5'-Triphosphate Trisodium Salt

Controlled Product

CAS: 122406-02-4

Formula: C₁₀H₁₁N₄Na₄O₁₂P₃

Color and Shape: Neat

Molecular weight: 564.094

Ref: TR-D440490

2',3'-Dideoxyinosine-5'-triphosphate triethylammonium salt

CAS: 122406-02-4

2',3'-Dideoxyinosine-5'-triphosphate triethylammonium salt (ddI-TP) is a nucleoside analog that inhibits HIV replication by competing with natural nucleosides for binding to HIV reverse transcriptase. ddI-TP acts as an inhibitor of human mitochondrial DNA polymerase γ, and blocks the synthesis of fatty acids in mouse cells. It is also able to inhibit signal pathways involving protein kinases and phosphatases. ddI-TP has been shown to be effective against hiv infection in mice. This drug can be used in the treatment of hiv infection, as well as in the prevention of its transmission from mother to child during pregnancy and breastfeeding.

Formula: C₁₀H₁₅N₄O₁₂P₃

Purity: Min. 95%

Molecular weight: 476.17 g/mol

Ref: 3D-ND10277