Ethyl 5-cyano-6-methyl-2-[(pyridin-4-ylsulfonyl)methyl]-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate, with CAS number 122576-86-7, is a complex organic compound characterized by its dihydropyridine structure, which is commonly associated with calcium channel blockers and other pharmacological agents. This compound features a cyano group, a sulfonyl moiety attached to a pyridine ring, and a trifluoromethyl-substituted phenyl group, contributing to its unique chemical properties and potential biological activity. The presence of these functional groups suggests that it may exhibit significant lipophilicity and potential interactions with biological targets, making it of interest in medicinal chemistry. Additionally, the ethyl ester group indicates that it may undergo hydrolysis to yield the corresponding carboxylic acid, which could further influence its pharmacokinetic profile. Overall, this compound's structural complexity and functional diversity suggest potential applications in drug development, particularly in the fields of cardiovascular and neurological therapeutics.

PD 122860 is a novel dihydropyridine with sodium channel stimulating and calcium channel blocking properties.  In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the shape of the electrocardiogram T-wave. PD 122860 selectively relaxed potassium-contracted aortic rings and inhibited [3H]nitrendipine binding to rat brain membranes, suggesting that the vasodilator activity of PD 122860 is due to Ca++ channel blockade.

ethyl 5-cyano-6-methyl-2-[(pyridin-4-ylsulfonyl)methyl]-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

122576-86-7: Ethyl 5-cyano-6-methyl-2-[(pyridin-4-ylsulfonyl)methyl]-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate, with CAS number 122576-86-7, is a complex organic compound characterized by its dihydropyridine structure, which is commonly associated with calcium channel blockers and other pharmacological agents. This compound features a cyano group, a sulfonyl moiety attached to a pyridine ring, and a trifluoromethyl-substituted phenyl group, contributing to its unique chemical properties and potential biological activity. The presence of these functional groups suggests that it may exhibit significant lipophilicity and potential interactions with biological targets, making it of interest in medicinal chemistry. Additionally, the ethyl ester group indicates that it may undergo hydrolysis to yield the corresponding carboxylic acid, which could further influence its pharmacokinetic profile. Overall, this compound's structural complexity and functional diversity suggest potential applications in drug development, particularly in the fields of cardiovascular and neurological therapeutics.

<p>PD 122860 is a dihydropyridine enhancing heart contractility, altering ECG, and relaxing aortic rings.</p>

CAS 122576-86-7

ethyl 5-cyano-6-methyl-2-[(pyridin-4-ylsulfonyl)methyl]-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

PD 122860

Ref: TM-T28321