CAS 122647-31-8

Ibutilide

Description:

Ibutilide is a class III antiarrhythmic agent primarily used in the management of atrial fibrillation and atrial flutter. It functions by prolonging the cardiac action potential and refractory period, which helps restore normal heart rhythm. Chemically, ibutilide is characterized by its structure, which includes a butyl side chain and an aromatic ring, contributing to its pharmacological properties. It is typically administered intravenously and is known for its rapid onset of action. The substance exhibits a moderate bioavailability and is metabolized primarily in the liver, with renal excretion of its metabolites. Common side effects may include QT interval prolongation, which can lead to potentially life-threatening arrhythmias, necessitating careful monitoring during administration. Due to its specific mechanism of action and potential side effects, ibutilide is generally reserved for use in a hospital setting under close supervision. Overall, ibutilide represents a critical option in the pharmacological management of certain cardiac arrhythmias, highlighting the importance of understanding its characteristics and effects in clinical practice.

Formula: C₂₀H₃₆N₂O₃S

InChI: InChI=1S/C20H36N2O3S/c1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25/h12-15,20-21,23H,4-11,16-17H2,1-3H3

InChI key: InChIKey=ALOBUEHUHMBRLE-UHFFFAOYSA-N

SMILES: C(CCCN(CCCCCCC)CC)(O)C1=CC=C(NS(C)(=O)=O)C=C1

Synonyms:

• Ibutilida
• Ibutilida [INN-Spanish]
• Ibutilide [INN:BAN]
• Ibutilidum
• Ibutilidum [INN-Latin]
• Methanesulfonamide, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-
• N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide (2E)-but-2-enedioate (salt)
• N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide
• Unii-2436Vx1U9B
• Ibutilide

Ibutilide

CAS: 122647-31-8

Formula: C₂₀H₃₆N₂O₃S

Molecular weight: 384.58

Ref: 7W-GP2164

Ibutilide

CAS: 122647-31-8

Ibutilide (U70226E) is an antiarrhythmic that prolongs action potential by blocking I Kr in AT-1 cells.

Formula: C₂₀H₃₆N₂O₃S

Color and Shape: Solid

Molecular weight: 384.58

Ref: TM-T61685

Ibutilide

CAS: 122647-31-8

Ibutilide is an antiarrhythmic drug that belongs to the class of drugs known as class III antiarrhythmics. It has a number of pharmacological effects in the heart, including slowing conduction through the AV node, increasing refractoriness of atrial and ventricular tissue, and blocking re-entrant circuits. Ibutilide has been shown to be effective in preventing or treating atrial fibrillation (AF), a type of arrhythmia, by acting on both the atria and ventricles. Ibutilide's use for AF is limited by its narrow therapeutic window, which can lead to toxic side effects such as torsades de pointes. The drug is also used for other types of arrhythmias such as paroxysmal supraventricular tachycardia (PSVT).

Formula: C₂₀H₃₆N₂O₃S

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 384.58 g/mol

Ref: 3D-FI37607

Ibutilide Hemifumarate

CAS: 122647-31-8, 122647-32-9

Formula: C₂₀H₃₆N₂O₃SC₄H₄O₄

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 442.62

Ref: 3B-I0946