CAS 1228-72-4

17-Epiestriol

Description:

17-Epiestriol, with the CAS number 1228-72-4, is a naturally occurring steroid hormone that is a derivative of estriol, which is one of the three main estrogens produced by the human body. It is characterized by its structure, which includes a phenolic A-ring and a hydroxyl group at the C-17 position, contributing to its estrogenic activity. This compound is primarily involved in the regulation of various physiological processes, including reproductive functions and menstrual cycles. 17-Epiestriol is known for its relatively weak estrogenic potency compared to other estrogens like estradiol. It is often studied in the context of hormone replacement therapy and its potential effects on bone density and cardiovascular health. Additionally, it has been investigated for its role in pregnancy, as it is produced in significant amounts by the placenta. Its solubility in organic solvents and its stability under physiological conditions make it a subject of interest in both clinical and research settings.

Formula: C₁₈H₂₄O₃

InChI: InChI=1/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17-,18+/m1/s1

InChI key: InChIKey=PROQIPRRNZUXQM-PNVOZDDCSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(C[C@@H](O)[C@H]2O)[H]

Synonyms:

• 17α-Estriol
• 17-Epiestriol
• Estra-1,3,5(10)-triene-3,16,17-triol, (16α,17α)-
• Estra-1,3,5(10)-triene-3,16α,17α-triol
• (16α,17α)-Estra-1,3,5(10)-triene-3,16,17-triol
• 16α-Hydroxy-17α-estradiol
• Conjugated Estrogens EP Impurity E
• 3,16ALPHA,17ALPHA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE
• 1,3,5(10)-Estratriene-3,16α,17α-triol, 16α-Hydroxy-17α-estradiol, 3,16α,17α-Trihydroxy-1,3,5(10)-estratriene
• 16a-Hydroxy-17a-estradiol
• 1,3,5[10]-ESTRATRIENE-3,16ALPHA,17ALPHA-TRIOL
• (8R,9S,13S,14S,16R,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
• Estra-1,3,5(10)-triene-3,16alpha,17
• 16ALPHA-HYDROXY-17ALPHA-ESTRADIOL
• Estriol IMpurity E
• Estriol EP Impurity E
• 1,3,5(10)-ESTRATRIEN-3,16-ALPHA, 17-ALPHA-TRIOL
• NSC84051
• 3,16-ALPHA,17-ALPHA-TRIHYDROXY-3,5(10)-ESTRATRIENE
• Estriol Impurity 5 (Estriol EP Impurity E)
• 16a,17a-Estriol
• 17-EPIESTRIOL (16ALPHA, 17ALPHA)

(16α,17α)-Estra-1,3,5(10)-triene-3,16,17-triol

CAS: 1228-72-4

Formula: C₁₈H₂₄O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 288.3814

Ref: IN-DA000JIE

Estriol EP Impurity E

CAS: 1228-72-4

Formula: C₁₈H₂₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 288.39

Ref: 4Z-E-354

17-Epiestriol

CAS: 1228-72-4

Formula: C₁₈H₂₄O₃

Purity: ≥ 97.0%

Color and Shape: Off-white to pale yellow powder or solid

Molecular weight: 288.38

Ref: 7W-GK6429

(8R,9S,13S,14S,16R,17S)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,16,17-triol (Estriol Impurity)

CAS: 1228-72-4

(8R,9S,13S,14S,16R,17S)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,16,17-triol (Estriol Impurity)

Purity: 98%

Ref: 54-OR1036652

17-Epiestriol

CAS: 1228-72-4

17-Epiestriol, metabolite of estrone, forms via 16α-hydroxy intermediate and binds ERα and ERβ with affinity less than 17β-estradiol.

Formula: C₁₈H₂₄O₃

Color and Shape: Solid

Molecular weight: 288.38

Ref: TM-T36913

Estra-1,3,5(10)-triene-3,16α,17α-triol (17-epi-Estriol)

Controlled Product

CAS: 1228-72-4

Formula: C₁₈H₂₄O₃

Color and Shape: Neat

Molecular weight: 288.38

Ref: 86-MM0130.05

17-Epiestriol

Controlled Product

CAS: 1228-72-4

Impurity Estriol EP Impurity E
Applications 17-Epiestriol (Estriol EP Impurity E) is a metabolite of Estradiol.
References Marrian, B., et al.: Biochem. J., 59, 136 (1955), Dietel, M., et al.: Cancer Res., 50, 6100 (1990), Schumacher, G., et al.: Clin. Cancer Res., 5, 493 (1999), Robert, J., et al.: J. Med. Chem., 46, 4805 (2003),

Formula: C₁₈H₂₄O₃

Color and Shape: White To Light Red

Molecular weight: 288.38

Ref: TR-E586510

17-Epiestriol-d5

Controlled Product

CAS: 1228-72-4

Applications A labelled metabolite of Estradiol (E888000).
References Marrian, B., et al.: Biochem. J., 59, 136 (1955), Dietel, M., et al.: Cancer Res., 50, 6100 (1990), Schumacher, G., et al.: Clin. Cancer Res., 5, 493 (1999), Robert, J., et al.: J. Med. Chem., 46, 4805 (2003),

Formula: C₁₈H₁₉D₅O₃

Color and Shape: Neat

Molecular weight: 293.41

Ref: TR-E586512

17-Epiestriol

Controlled Product

CAS: 1228-72-4

17-Epiestriol is a weak estrogen that regulates the menstrual cycle, prevents pre-eclampsia, and decreases the risk of cardiovascular disease. 17-Epiestriol is sometimes used to treat menopausal symptoms. The concentration of 17-epiestriol in blood plasma is determined by body mass index (BMI). This hormone plays an important role in maintaining a woman's health during her reproductive years. It has been shown that there is a negative correlation between levels of 17-epiestriol and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Preterm birth may be due to lack of 17-epiestriol.

Formula: C₁₈H₂₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 288.38 g/mol

Ref: 3D-FE22725

Estriol EP Impurity E

CAS: 1228-72-4

Formula: C₁₈H₂₄O₃

Molecular weight: 288.4

Ref: ST-EA-CP-E28005