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CAS 1228105-52-9

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Maytansine, N2′-deacetyl-N2′-[4-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-4-methyl-1-oxopentyl]-

Description:
Maytansine is a potent antitumor agent derived from the plant Maytenus serrata. The compound is characterized by its complex structure, which includes a maytansinoid core that contributes to its cytotoxic properties. It functions primarily as a microtubule inhibitor, disrupting the normal function of the mitotic spindle during cell division, which ultimately leads to cell death. The specific derivative you mentioned, N2′-deacetyl-N2′-[4-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-4-methyl-1-oxopentyl]- is a modified form that may enhance its therapeutic efficacy or alter its pharmacokinetic properties. Maytansine and its derivatives are of significant interest in cancer research, particularly in the development of antibody-drug conjugates (ADCs), which aim to deliver cytotoxic agents selectively to cancer cells while minimizing damage to healthy tissues. Its use in clinical settings is being explored, highlighting its potential as a valuable tool in targeted cancer therapy.
Formula:C54H72ClN5O16S
InChI:InChI=1S/C54H72ClN5O16S/c1-29-12-11-13-39(72-10)54(70)27-37(73-51(69)56-54)30(2)47-53(6,75-47)40(26-44(64)58(8)35-23-33(22-29)24-36(71-9)46(35)55)74-49(67)31(3)57(7)41(61)20-21-52(4,5)77-38-25-45(65)59(48(38)66)28-32-14-16-34(17-15-32)50(68)76-60-42(62)18-19-43(60)63/h11-13,23-24,30-32,34,37-40,47,70H,14-22,25-28H2,1-10H3,(H,56,69)/b13-11+,29-12+/t30-,31+,32?,34?,37+,38?,39-,40+,47+,53+,54+/m1/s1
InChI key:InChIKey=VYNFFBGYRBMGDS-NPCPMBKGSA-N
SMILES:C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCC(SC5C(=O)N(CC6CCC(C(ON7C(=O)CCC7=O)=O)CC6)C(=O)C5)(C)C)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]
Synonyms:
  • Maytansine, N2′-deacetyl-N2′-[4-[[1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-2,5-dioxo-3-pyrrolidinyl]thio]-4-methyl-1-oxopentyl]-
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Found 2 products.
  • DM4-SMCC
    Targetmol
    + Info

    DM4-SMCC

    CAS:
    DM4-SMCC, a non-cleavable drug-linker conjugate for antibody-drug conjugates (ADC), leverages the antitumor efficacy of DM4 (an antitubulin agent) through
    Formula:C54H72ClN5O16S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1114.69

    Ref: TM-T17833

  • SMCC-DM4
    TRC
    + Info

    SMCC-DM4

    Controlled Product
    CAS:
    Formula:C54H72ClN5O16S
    Color and Shape:Neat
    Molecular weight:1114.691

    Ref: TR-S565020

    1mg
    1,022.00€