CAS 122852-42-0

Alosetron

Description:

Alosetron is a selective serotonin 5-HT3 receptor antagonist primarily used in the treatment of irritable bowel syndrome (IBS) in women with severe symptoms. It works by modulating the activity of serotonin in the gastrointestinal tract, thereby reducing bowel motility and alleviating symptoms such as abdominal pain and diarrhea. Alosetron is characterized by its chemical formula, which includes elements such as carbon, hydrogen, nitrogen, and oxygen. The substance is typically administered orally and has a specific pharmacokinetic profile, including absorption, distribution, metabolism, and excretion characteristics that influence its therapeutic efficacy and safety. Due to its mechanism of action, alosetron can have side effects, including constipation and potential serious gastrointestinal complications, which necessitate careful patient selection and monitoring. It is important to note that alosetron is subject to regulatory controls and is prescribed under specific conditions to mitigate risks associated with its use.

Formula: C₁₇H₁₈N₄O

InChI: InChI=1/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19)

InChI key: InChIKey=JSWZEAMFRNKZNL-UHFFFAOYSA-N

SMILES: O=C1C=2C=3C(N(C)C2CCN1CC4=C(C)N=CN4)=CC=CC3

Synonyms:

• 1H-Pyrido(4,3-b)indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-((5-methyl-1H-imidazol-4-yl)methyl)-
• 1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-
• 2,3,4,5-Tetrahydro-5-methyl-2-((5-methyl-1H-imidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one
• 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one
• 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
• Alosetron [INN:BAN]
• Gr 68755
• Gr 68755X
• Lotronex
• Unii-13Z9Hth115
• Alosetron
• 5-Methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
• GR 68755; GR 68755X; LOTRONEX;GR-68755;GR68755
• 5-METHYL-2-[(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]-3,4-DIHYDROPYRIDO[4,3-B]INDOL-1-ONE
• GR-68755X;GR-68755

Alosetron Hydrochloride

CAS: 122852-42-0, 122852-69-1

Formula: C₁₇H₁₈N₄O·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 330.82

Ref: 3B-A3197

2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one

CAS: 122852-42-0

Formula: C₁₇H₁₈N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 294.3510

Ref: IN-DA019FUV

Alosetron

CAS: 122852-42-0

Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.

Formula: C₁₇H₁₈N₄O

Purity: 98%

Color and Shape: Crystalline Powder

Molecular weight: 294.36

Ref: TM-T21235

Alosetron

CAS: 122852-42-0

Formula: C₁₇H₁₈N₄O

Molecular weight: 294.35

Ref: 7W-GP3897

Alosetron

Controlled Product

CAS: 122852-42-0

Alosetron is a 5-HT3 receptor antagonist that is used in the treatment of severe diarrhea-predominant irritable bowel syndrome (IBS). Alosetron has been shown to decrease the frequency of spontaneous contractions and increase the number of contractions induced by acetylcholine in the rabbit ileum. Alosetron also inhibits activity of kappa opioid receptors and enzymes such as esterases, carboxylesterases, and phospholipases. Toxicity studies have shown that alosetron does not affect male reproductive organs or female fertility.

Purity: Min. 95%

Ref: 3D-FA43705