CAS 122852-69-1

Alosetron hydrochloride

Description:

Alosetron hydrochloride is a selective serotonin 5-HT3 receptor antagonist primarily used in the treatment of irritable bowel syndrome (IBS) in women with severe symptoms. It works by modulating the activity of serotonin in the gastrointestinal tract, thereby reducing bowel motility and alleviating symptoms such as abdominal pain and diarrhea. The compound is characterized by its hydrochloride salt form, which enhances its solubility and stability. Alosetron is typically administered orally and is known for its efficacy in managing IBS, although it is associated with potential side effects, including constipation and, in rare cases, serious gastrointestinal complications. Due to these risks, its use is restricted and monitored in clinical settings. The chemical structure of alosetron includes a fused indole ring system, contributing to its pharmacological properties. As with any medication, it is essential to consider patient-specific factors and potential drug interactions when prescribing alosetron hydrochloride.

Formula: C₁₇H₁₈N₄O·ClH

InChI: InChI=1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H

InChI key: InChIKey=FNYQZOVOVDSGJH-UHFFFAOYSA-N

SMILES: O=C1C=2C=3C(N(C)C2CCN1CC4=C(C)N=CN4)=CC=CC3.Cl

Synonyms:

• 1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-, hydrochloride (1:1)
• 1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-, monohydrochloride
• 2,3,4,5-Tetrahydro-5-Methyl-2-[(5-Methyl-1H-Imidazol-4-Yl)Methyl]-1H-Pyrido[4,3-B]Indol-1-One Hydrochloride
• 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride
• 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one hydrochloride (1:1)
• Alosetron Hcl
• Gr 68755C
• Gr 68755X
• Alosetron hydrochloride

Alosetron Hydrochloride

CAS: 122852-42-0, 122852-69-1

Formula: C₁₇H₁₈N₄O·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 330.82

Ref: 3B-A3197

Alosetron Hydrochloride (2,3,4,5-Tetrahydro-5-methyl-2-[(5-methylimidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride)

CAS: 122852-69-1

Lactams not elsewhere specified or included

Formula: C₁₇H₁₈N₄O·HCl

Color and Shape: White Beige Solid

Molecular weight: 330.12474

Ref: 45-1013807

Alosetron hydrochloride

CAS: 122852-69-1

Alosetron hydrochloride (GR 68755), a selective 5-HT3 receptor antagonist, can block the actions of serotonin at 5-HT3 sites in the peripheral nervous system.

Formula: C₁₇H₁₉ClN₄O

Purity: 99.90%

Color and Shape: Off-White Powder

Molecular weight: 330.81

Ref: TM-T2525

Alosetron (hydrochloride)

CAS: 122852-69-1

Formula: C₁₇H₁₉ClN₄O

Purity: 97%

Color and Shape: Solid

Molecular weight: 330.8120

Ref: IN-DA000JLR

Alosetron HCl

CAS: 122852-69-1

Formula: C₁₇H₁₈N₄O·HCl

Color and Shape: Off-White Solid

Molecular weight: 294.36 36.46

Ref: 4Z-A-652

Alosetron hydrochloride

CAS: 122852-69-1

Formula: C₁₇H₁₉ClN₄O

Molecular weight: 330.81

Ref: 7W-GP5917

Alosetron Hydrochloride

Controlled Product

CAS: 122852-69-1

Formula: C₁₇H₁₈N₄O·ClH

Color and Shape: Neat

Molecular weight: 330.81

Ref: 86-MM3508.00

Alosetron HCl - Bio-X ™

Controlled Product

CAS: 122852-69-1

Alosetron is a serotonin 5-HT3 receptor antagonist that is used for the treatment and management of severe diarrhoea- predominant irritable bowel syndrome. The regulation of processes connected to IBS such as visceral discomfort, colonic transit, and GI secretions is impacted by the activation of the 5-HT3 receptors and resulting neuronal depolarization. Alosetron manages IBS by inhibiting these receptors.

Formula: C₁₇H₁₈N₄O•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 330.81 g/mol

Ref: 3D-BA166465

Alosetron HCl

Controlled Product

CAS: 122852-69-1

Serotonin 5-HT3 receptor antagonist

Formula: C₁₇H₁₉ClN₄O

Purity: Min. 95%

Color and Shape: White Slightly Brown Powder

Molecular weight: 330.81 g/mol

Ref: 3D-FA17322

Alosetron Hydrochloride

Controlled Product

CAS: 122852-69-1

Applications Serotonin 5HT3-receptor antagonist. Used in treatment of irritable bowel syndrome.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Camilleri, M., et al.: Lancet, 355, 1035 (2000), Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002), Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003), Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006), Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007),

Formula: C₁₇H₁₈N₄O·ClH

Color and Shape: Neat

Molecular weight: 330.81

Ref: TR-A575500