CAS 1228690-36-5

[4′-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid

Description:

The chemical substance with the name "[4′-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid" and CAS number "1228690-36-5" is a complex organic compound characterized by its unique structural features, including a biphenyl core, an isoxazole ring, and an acetic acid moiety. This compound likely exhibits specific biological activity due to its intricate arrangement of functional groups, which may influence its interactions with biological targets. The presence of the (R)-1-phenylethyl group suggests potential chiral properties, which can affect its pharmacokinetics and pharmacodynamics. Additionally, the isoxazole ring may contribute to its stability and reactivity, making it a candidate for various applications in medicinal chemistry. The compound's solubility, melting point, and other physical properties would depend on its molecular interactions and the presence of polar or nonpolar groups. Overall, this substance represents a class of compounds that may have therapeutic potential, warranting further investigation into its biological effects and mechanisms of action.

Formula: C₂₇H₂₄N₂O₅

InChI: InChI=1S/C27H24N2O5/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31)/t18-/m1/s1

InChI key: InChIKey=LNDDRUPAICPXIN-GOSISDBHSA-N

SMILES: N(C(O[C@H](C)C1=CC=CC=C1)=O)C2=C(ON=C2C)C3=CC=C(C=C3)C4=CC=C(CC(O)=O)C=C4

Synonyms:

• (R)-2-(4′-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1′-biphenyl]-4-yl)acetic acid
• 4′-[3-Methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1′-biphenyl]-4-acetic acid
• [4′-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid
• [1,1′-Biphenyl]-4-acetic acid, 4′-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-

AM095 free acid

CAS: 1228690-36-5

AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).

Formula: C₂₇H₂₄N₂O₅

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 456.49

Ref: TM-T10293

[1,1'-Biphenyl]-4-acetic acid, 4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-

CAS: 1228690-36-5

Formula: C₂₇H₂₄N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 456.4899

Ref: IN-DA000JNM

AM095 free acid

CAS: 1228690-36-5

AM095 free acid

Purity: ≥98%

Molecular weight: 456.49g/mol

Ref: 54-BUP07041

AM095 Free Acid

CAS: 1228690-36-5

AM095 Free Acid

Purity: 98%

Color and Shape: Solid

Molecular weight: 456.49g/mol

Ref: 54-BISN0022

AM095 Free Acid

CAS: 1228690-36-5

AM095 Free Acid is a small molecule that binds to the extracellular domain of the β2-adrenergic receptor (β2AR) and inhibits its activity. This drug is being developed for the treatment of chronic cough, asthma, and mda-mb-231 breast cancer. The intracellular Ca2+ levels are increased by AM095 Free Acid in vivo and in vitro. AM095 Free Acid has been shown to inhibit axonal growth in vivo and in vitro by binding to the basic protein of nerve cells. This drug also has a protective effect on kidney fibrosis induced by collagen gel. AM095 Free Acid has been shown to inhibit bacterial growth, which may be due to its ability to bind with polymerase chain reaction (PCR) primers that are used for DNA amplification or other biological samples such as growth factor-β1.

Formula: C₂₇H₂₄N₂O₅

Purity: Min. 95%

Molecular weight: 456.49 g/mol

Ref: 3D-DZB69036