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CAS 1228923-42-9

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14,19-Dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 11-[2-(1-pyrrolidinyl)ethoxy]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Description:
The chemical substance known as 14,19-Dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 11-[2-(1-pyrrolidinyl)ethoxy]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) with CAS number 1228923-42-9 is a complex organic compound characterized by its intricate polycyclic structure, which includes multiple nitrogen and oxygen atoms. This compound features a tetracyclic framework, indicative of its potential biological activity and interaction with various biological systems. The presence of functional groups such as the pyrrolidinyl moiety and the tricarboxylate suggests that it may exhibit solubility in polar solvents and could participate in hydrogen bonding. Its structural complexity may contribute to unique pharmacological properties, making it of interest in medicinal chemistry. Additionally, the presence of hydroxyl and ether functionalities may enhance its reactivity and interaction with other molecules. Overall, this compound's unique architecture and functional groups position it as a potentially valuable candidate for further research in drug development and chemical synthesis.
Formula:C34H40N4O10
Synonyms:
  • Pacritinib Citrate
  • Pacetinib citrate
  • 14,19-Dioxa-5,7,27-triazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 11-[2-(1-pyrrolidinyl)ethoxy]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
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  • Pacritinib citrate
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    Pacritinib citrate

    CAS:
    <p>Pacritinib (SB1518) citrate effectively inhibits wild-type JAK2 (IC 50 =23 nM) and the JAK2 V617F mutant (IC 50 =19 nM). It also targets FLT3 (IC 50 =22 nM) and the FLT3 D835Y mutant (IC 50 =6 nM). This compound is utilized in the study of acute myeloid leukemia (AML) and myelofibrosis (MF) [1] [2] [3].</p>
    Formula:C34H40N4O10
    Color and Shape:Solid
    Molecular weight:664.7

    Ref: TM-T87094