CAS 1229-29-4

Doxepin hydrochloride

Description:

Doxepin hydrochloride is a tricyclic antidepressant primarily used to treat depression and anxiety disorders, as well as insomnia. It functions by inhibiting the reuptake of neurotransmitters such as norepinephrine and serotonin, thereby enhancing mood and promoting sleep. This compound appears as a white to off-white crystalline powder and is soluble in water, making it suitable for various pharmaceutical formulations. Doxepin hydrochloride exhibits a relatively long half-life, allowing for once-daily dosing in many cases. Its pharmacological effects can include sedation, which is beneficial for patients with sleep disturbances. However, it may also lead to side effects such as dry mouth, dizziness, and weight gain. Due to its anticholinergic properties, caution is advised in patients with certain pre-existing conditions, such as glaucoma or urinary retention. Overall, doxepin hydrochloride is a versatile medication with a well-established profile in the management of mood and sleep disorders.

Formula: C₁₉H₂₁NO·ClH

InChI: InChI=1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H

InChI key: InChIKey=MHNSPTUQQIYJOT-UHFFFAOYSA-N

SMILES: C(CCN(C)C)=C1C=2C(COC=3C1=CC=CC3)=CC=CC2.Cl

Synonyms:

• (3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine hydrochloride
• (3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine hydrochloride
• 1-Propanamine, 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-, hydrochloride (1:1)
• 1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-, hydrochloride
• 11-(3-Dimethylaminopropylidene)-6,11-Dihydro-Benz[B,E]Oxepin Hcl
• 3-(6,11-Dihydrodibenz(B,E)Oxepin-11-Ylidene)Propyldimethylamine Hcl
• 3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine hydrochloride (1:1)
• Adapin
• Aponal
• Curatin
• Dibenz[b,e]oxepin, 1-propanamine deriv.
• Dibenz[b,e]oxepin-Δ¹¹⁽⁶^H^),γ-propylamine, N,N-dimethyl-, hydrochloride
• Doxepin Hydrochloride
• Doxepine hydrochloride
• N,N-Dimethyldibenz[b,e]oxepin-Δ¹¹⁽⁶^H^),γ-propylamine hydrochloride
• P 3693A
• Quitaxon
• Silenor
• Sinequan
• Sinequin
• DOXEPINONE HCl

Doxepin Hydrochloride

Controlled Product

CAS: 1229-29-4

Stability Hygroscopic
Applications Doxepin is used clinically to treat anxiety and depression. Doxepin is an antidepressant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ribbentrop, A., et al.: Arzneim.-Forsch., 15, 863 (1965); Hobbs, D.C., et al.: Biochem. Pharmacol., 18, 1941 (1969); Pinder, R.M., et al.: Drugs, 13, 161 (1977); Shrivastava, R.K., et al.: Clin. Ther., 7, 181 (1985);

Formula: C₁₉H₂₁NO·ClH

Color and Shape: Neat

Molecular weight: 315.84

Ref: TR-D550000

Doxepin-13C, d3 .xHydrochloride

Controlled Product

CAS: 1229-29-4

Formula: C₁₈CH₁₈D₃NO•x(HCl)

Color and Shape: Neat

Molecular weight: 318.15782

Ref: TR-D550003

Doxepin hydrochloride

Controlled Product

CAS: 1229-29-4

Histamine receptor H1 antagonist; tricyclic antidepressant

Formula: C₁₉H₂₂ClNO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 315.84 g/mol

Ref: 3D-FD22604

Doxepin HCl - Bio-X ™

Controlled Product

CAS: 1229-29-4

Doxepin is a psychotropic agent that is used in the treatment of depression, anxiety and insomnia. This drug has antidepressant and anxiolytic properties. This mechanism of action for this drug is not clear however it is known to be a histamine receptor antagonist.

Formula: C₁₉H₂₁NO•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 315.84 g/mol

Ref: 3D-BD166235