CAS 1229208-44-9

Entospletinib

Description:

Entospletinib is a small molecule inhibitor primarily targeting the spleen tyrosine kinase (SYK), which plays a crucial role in various signaling pathways, particularly in immune responses and inflammation. This compound is characterized by its ability to modulate immune cell activity, making it a candidate for therapeutic applications in autoimmune diseases and certain types of cancer. Entospletinib exhibits a relatively high selectivity for SYK over other kinases, which is essential for minimizing off-target effects and enhancing its therapeutic profile. The substance is typically administered in a clinical setting, and its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for determining its efficacy and safety. Additionally, ongoing research is focused on understanding its potential benefits and limitations in various treatment regimens, particularly in hematological malignancies and inflammatory disorders. As with many investigational drugs, the full spectrum of its pharmacological effects and potential side effects is still being evaluated through clinical trials.

Formula: C₂₃H₂₁N₇O

InChI: InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)

InChI key: InChIKey=XSMSNFMDVXXHGJ-UHFFFAOYSA-N

SMILES: N(C=1C=2N(C=C(N1)C=3C=C4C(=CC3)C=NN4)C=CN2)C5=CC=C(C=C5)N6CCOCC6

Synonyms:

• Imidazo[1,2-a]pyrazin-8-amine, 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-
• 6-(1H-Indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]imidazo[1,2-a]pyrazin-8-amine
• GS 9973
• Entospletinib

Imidazo[1,2-a]pyrazin-8-amine, 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-

CAS: 1229208-44-9

Formula: C₂₃H₂₁N₇O

Purity: %

Color and Shape: Solid

Molecular weight: 411.4591

Ref: IN-DA000JRH

6-(1H-Indazol-6-Yl)-N-(4-Morpholinophenyl)Imidazo[1,2-a]Pyrazin-8-Amine

CAS: 1229208-44-9

6-(1H-Indazol-6-Yl)-N-(4-Morpholinophenyl)Imidazo[1,2-a]Pyrazin-8-Amine

Purity: 99+%

Molecular weight: 411.46g/mol

Ref: 54-OR1024020

Entospletinib

CAS: 1229208-44-9

Entospletinib

Purity: ≥98%

Molecular weight: 411.46g/mol

Ref: 54-BUP08570

Entospletinib (GS-9973)

CAS: 1229208-44-9

Formula: C₂₃H₂₁N₇O

Molecular weight: 411.47

Ref: 4Z-K-031075

Entospletinib

CAS: 1229208-44-9

Entospletinib (GS-9973) is a Syk inhibitor (IC50=7.7 nM) with selective, oral activity. High-Quality, Low-Cost!

Formula: C₂₃H₂₁N₇O

Purity: 98.54% - 99.74%

Color and Shape: Solid

Molecular weight: 411.46

Ref: TM-T6101

Entospletinib

CAS: 1229208-44-9

Purity: 99+%

Molecular weight: 411.181

Ref: 10-F865545

GS 9973

CAS: 1229208-44-9

Applications GS 9973 is a selective and orally bioavailable inhibitor of spleen tyrosine kinase (Syk).
References Currie, K.S., et. al.: J. Med. Chem., 57, 3856 (2014);

Formula: C₂₃H₂₁N₇O

Color and Shape: Neat

Molecular weight: 411.46

Ref: TR-G797250

GS 9973

CAS: 1229208-44-9

GS 9973 is a research drug that inhibits the activity of protein kinases, which are enzymes that regulate the function of other proteins. GS 9973 inhibits the activity of mcl-1, an effector protein in the apoptosis pathway and is currently being tested for its ability to inhibit cancer cells from spreading. GS 9973 has been shown to have a low risk of toxicity in humans and has been found to be safe for use in clinical trials with human pharmacokinetics. This drug also inhibits P-gp substrates, which prevents it from entering into the retina. The only side effects observed so far are eye disorders such as conjunctivitis and iritis.

Formula: C₂₃H₂₁N₇O

Purity: Min. 95%

Molecular weight: 411.47 g/mol

Ref: 3D-EZB20844