CAS 122970-40-5

7-thia-8-oxoguanosine

Description:

7-Thia-8-oxoguanosine is a modified nucleoside that features a sulfur atom in place of the oxygen at the 7-position of the guanine base, along with an oxo group at the 8-position. This structural modification imparts unique biochemical properties to the molecule, influencing its stability and reactivity compared to standard nucleosides. It is known to participate in various biological processes, including those related to RNA metabolism and cellular signaling. The presence of the sulfur atom can affect hydrogen bonding and base pairing, potentially impacting the molecule's role in nucleic acid interactions. Additionally, 7-thia-8-oxoguanosine may exhibit altered affinity for enzymes and receptors, making it of interest in pharmacological research. Its potential applications include serving as a tool in studying RNA structure and function, as well as in the development of therapeutic agents targeting nucleic acid pathways. Overall, this compound represents a significant area of study in the field of nucleoside chemistry and molecular biology.

Formula: C₁₀H₁₂N₄O₆S

InChI: InChI=1/C10H12N4O6S/c11-9-12-6-5(7(18)13-9)21-10(19)14(6)8-4(17)3(16)2(1-15)20-8/h2-4,8,15-17H,1H2,(H3,11,12,13,18)/t2-,3-,4-,8-/m1/s1

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2c3c(c(nc(=N)[nH]3)O)sc2=O)O1)O)O)O

Synonyms:

• Isatoribine [USAN:INN]
• 5-Amino-3-ribofuranosylthiazolo(4,5-d)pyrimidine-2,7(3H,6H)-dione
• 7-Deaza-7-thia-8-oxoguanosine
• 7-Tog
• Ana245
• Isatoribine
• Unii-2Dnt962H92
• Thiazolo(4,5-d)pyrimidine-2,7(3H,4H)-dione, 5-amino-3-beta-D-ribofuranosyl-
• 5-amino-3-(beta-D-ribofuranosyl)[1,3]thiazolo[4,5-d]pyrimidine-2,7(3H,4H)-dione

Isatoribine

CAS: 122970-40-5

Isatoribine

Purity: ≥98%

Molecular weight: 316.29g/mol

Ref: 54-BUP07301

5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione

CAS: 122970-40-5

5-Amino-3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidin-2,7(3H,6H)-dione (ATZ) is a prodrug that is converted to the active drug ATZ. ATZ has been shown to be effective against hepatitis C virus in vitro assays and in vivo in animal models. It inhibits viral replication by inhibiting the protein synthesis of the virus and its ability to replicate. ATZ also has been shown to be effective against infectious diseases such as herpes simplex virus, inflammatory diseases such as rheumatoid arthritis, and cancer. The drug is an oral prodrug that must be activated by intestinal bacteria before it can be absorbed into the bloodstream. It is chemically stable and does not undergo significant metabolism after being absorbed into the body.

Formula: C₁₀H₁₂N₄O₆S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 316.29 g/mol

Ref: 3D-XEA97040

Isatoribine

Controlled Product

CAS: 122970-40-5

Formula: C₁₀H₁₂N₄O₆S

Color and Shape: Neat

Molecular weight: 316.29

Ref: TR-I777603

Isatoribine

CAS: 122970-40-5

Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.

Formula: C₁₀H₁₂N₄O₆S

Purity: 98.99% - 99.75%

Color and Shape: Solid

Molecular weight: 316.29

Ref: TM-T24178