CAS 122970-43-8

7-THIO-8-OXOGUANOSINE

Description:

7-Thio-8-oxoguanosine is a modified nucleoside that features a thiol group at the 7-position and an oxo group at the 8-position of the guanine base. This compound is of interest in biochemical research due to its potential roles in cellular processes and its implications in oxidative stress and nucleic acid metabolism. The presence of the thiol group may influence its reactivity and interactions with other biomolecules, while the 8-oxo modification is often associated with oxidative damage to DNA and RNA. As a nucleoside, it consists of a ribose sugar linked to the modified guanine base, which can participate in various biochemical pathways, including those related to RNA synthesis and function. The compound's unique structural features may also make it a subject of study in the context of drug development and therapeutic applications, particularly in understanding the mechanisms of nucleic acid damage and repair. Overall, 7-thio-8-oxoguanosine represents a significant area of interest in the fields of molecular biology and medicinal chemistry.

Formula: C₁₀H₁₂N₄O₆S

InChI: InChI=1/C10H12N4O6S/c11-9-12-6-5(7(18)13-9)21-10(19)14(6)8-4(17)3(16)2(1-15)20-8/h2-4,8,15-17H,1H2,(H3,11,12,13,18)/t2-,3+,4?,8-/m1/s1

Synonyms:

• 3-b-D-ribofuranosylthiazolo[4,5-d]pyrimidine-2,7-(3H,6H)-dione
• 8-Oxo-7-thio-D-guanosine
• 3--D-ribofuranosylthiazolo[4,5-d]pyrimidine-2,7-(3H,6H)-dione

Thiazolo[4,5-d]pyrimidine-2,7(3H,4H)-dione, 3-β-D-ribofuranosyl- (9CI)

CAS: 122970-43-8

Formula: C₁₀H₁₂N₄O₆S

Color and Shape: Solid

Molecular weight: 316.2905

Ref: IN-DA000JUI

8-Oxo-7-thioguanosine

CAS: 122970-43-8

Ref: 7W-GN4265

7-Thio-8-oxoguanosine

Controlled Product

CAS: 122970-43-8

Formula: C₁₀H₁₂N₄O₆S

Color and Shape: Neat

Molecular weight: 316.29

Ref: TR-T344600

8-Oxo-7-thioguanosine

CAS: 122970-43-8

8-Oxoguanosine monophosphate (8-oxoGMP) is a synthetic nucleoside that is activated by the enzyme thioredoxin reductase and phosphorylated to form 8-oxoGTP. The anticancer activity of 8-oxoGMP is due to its ability to inhibit ribonucleotide reductase, which reduces the production of DNA and RNA in cells. This product has been shown to inhibit HIV replication in vitro and in vivo. It also inhibits viral replication by inhibiting the synthesis of viral nucleic acids such as DNA, RNA, and deoxyribonucleic acid (DNA).

Formula: C₁₀H₁₂N₄O₆S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 316.29 g/mol

Ref: 3D-NO02817