CAS 1229705-06-9

Idasanutlin

Description:

Idasanutlin is a small molecule inhibitor that primarily targets the MDM2 protein, which is known for its role in regulating the p53 tumor suppressor pathway. By inhibiting MDM2, Idasanutlin promotes the stabilization and activation of p53, leading to increased apoptosis in cancer cells that rely on MDM2 for survival. This compound is particularly relevant in the treatment of various malignancies, including those with wild-type p53, as it can restore the function of this critical tumor suppressor. Idasanutlin is typically administered orally and has been evaluated in clinical trials for its efficacy and safety in treating hematological malignancies and solid tumors. Its mechanism of action highlights the importance of the p53 pathway in cancer biology, making it a significant candidate in targeted cancer therapies. Additionally, Idasanutlin's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for understanding its therapeutic potential and optimizing treatment regimens.

Benzoic acid, 4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-

CAS: 1229705-06-9

Formula: C₃₁H₂₉Cl₂F₂N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 616.4825

Ref: IN-DA000JU9

4-((2R,3S,4R,5S)-3-(3-Chloro-2-Fluorophenyl)-4-(4-Chloro-2-Fluorophenyl)-4-Cyano-5-Neopentylpyrrolidine-2-Carboxamido)-3-Methoxybenzoic Acid

CAS: 1229705-06-9

4-((2R,3S,4R,5S)-3-(3-Chloro-2-Fluorophenyl)-4-(4-Chloro-2-Fluorophenyl)-4-Cyano-5-Neopentylpyrrolidine-2-Carboxamido)-3-Methoxybenzoic Acid

Purity: 98%

Molecular weight: 616.48g/mol

Ref: 54-PC108393

Idasanutlin

CAS: 1229705-06-9

Idasanutlin

Purity: ≥98%

Molecular weight: 616.48g/mol

Ref: 54-BUP13108

Idasanutlin

CAS: 1229705-06-9

Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).

Formula: C₃₁H₂₉Cl₂F₂N₃O₄

Purity: 99.13% - 99.88%

Color and Shape: Solid

Molecular weight: 616.48

Ref: TM-T6254

Idasanutlin

CAS: 1229705-06-9

Purity: 99.90%

Molecular weight: 616.49

Ref: 10-F978951

Idasanutlin

Controlled Product

CAS: 1229705-06-9

Applications Idasanutlin is an MDM2 inihibtor, blocking the p53 protein-protein interaction and may be used in anti-cancer treatments.
References Zhao, Y. et al.: J. Med. Chem., 58, 1038 (2015); Chen, L. et al.: Brit. J. Cancer., 111, 716 (2014);

Formula: C₃₁H₂₉Cl₂F₂N₃O₄

Color and Shape: White To Off-White

Molecular weight: 616.48

Ref: TR-I167030

RG 7388

CAS: 1229705-06-9

Inhibitor of MDM2 E3 ubiquitin-protein ligase and MRP1 transporter

Formula: C₃₁H₂₉Cl₂F₂N₃O₄

Purity: Min. 95%

Color and Shape: White To Light (Or Pale) Yellow Solid

Molecular weight: 616.48 g/mol

Ref: 3D-FR104258