CAS 123039-99-6

Azasetron

Description:

Azasetron is a chemical compound classified as a selective serotonin 5-HT3 receptor antagonist, primarily used in the context of antiemetic therapy to prevent nausea and vomiting, particularly in patients undergoing chemotherapy or surgery. Its structure features a bicyclic framework that includes a nitrogen atom, which contributes to its pharmacological activity. Azasetron exhibits high affinity for the 5-HT3 receptors, blocking the action of serotonin, a neurotransmitter involved in the vomiting reflex. The compound is typically administered orally and is known for its relatively favorable side effect profile compared to other antiemetics. In terms of solubility, Azasetron is generally soluble in organic solvents, which facilitates its formulation in pharmaceutical preparations. Its efficacy and safety have been evaluated in various clinical studies, making it a valuable option in the management of chemotherapy-induced nausea and vomiting. As with any medication, it is essential to consider potential interactions and contraindications when prescribing Azasetron.

Formula: C₁₇H₂₀ClN₃O₃

InChI: InChI=1/C17H20ClN3O3/c1-20-13-9-11(18)8-12(15(13)24-10-14(20)22)16(23)19-17-2-5-21(6-3-17)7-4-17/h8-9H,2-7,10H2,1H3,(H,19,23)

InChI key: InChIKey=WUKZPHOXUVCQOR-UHFFFAOYSA-N

SMILES: C(NC1C2CCN(C1)CC2)(=O)C3=C4C(N(C)C(=O)CO4)=CC(Cl)=C3

Synonyms:

• (±)-N-(1-azabicyclo[2,2,2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
• 2H-1,4-Benzoxazine-8-carboxamide, N-1-azabicyclo(2.2.2)oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-, monohydrochloride
• 2H-1,4-Benzoxazine-8-carboxamide,N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-
• 6-chloro-4-methyl-3-oxo-N-quinuclidin-4-yl-1,4-benzoxazine-8-carboxamide
• Asasetron
• Azasetron [superceded rn]
• N-(1-Azabicyclo[2.2.2]Oct-3-Yl)-6-Chloro-4-Methyl-3-Oxo 3,4-Dihydro-2H-1,4-Benzoxazine-8-Carboxamide
• N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxamide
• Nazasetron
• Nazasetron Azasetron
• Azasetron