CAS 123122-54-3

Candoxatrilat

Description:

Candoxatrilat is a chemical compound primarily recognized for its role as an angiotensin-converting enzyme (ACE) inhibitor. It is characterized by its ability to modulate blood pressure and is often studied for its potential therapeutic applications in cardiovascular diseases. The compound features a specific molecular structure that allows it to interact effectively with the ACE enzyme, thereby inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This inhibition leads to vasodilation and a subsequent decrease in blood pressure. Candoxatrilat is typically administered in a pharmaceutical context, and its efficacy and safety profile have been evaluated in various clinical studies. As with many ACE inhibitors, potential side effects may include cough, elevated potassium levels, and hypotension. Its chemical properties, such as solubility and stability, are crucial for formulation in drug development. Overall, Candoxatrilat represents a significant compound in the field of antihypertensive therapy, contributing to the management of hypertension and related cardiovascular conditions.

Formula: C₂₀H₃₃NO₇

InChI: InChI=1S/C20H33NO7/c1-27-10-11-28-13-15(18(24)25)12-20(8-2-3-9-20)19(26)21-16-6-4-14(5-7-16)17(22)23/h14-16H,2-13H2,1H3,(H,21,26)(H,22,23)(H,24,25)/t14-,15-,16+/m0/s1

InChI key: InChIKey=ACZWIDANLCXHBM-HRCADAONSA-N

SMILES: C([C@@H](COCCOC)C(O)=O)C1(C(N[C@H]2CC[C@@H](C(O)=O)CC2)=O)CCCC1

Synonyms:

• U 73967
• UK 73967
• Cyclohexanecarboxylic acid, 4-[[[1-[(2S)-2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentyl]carbonyl]amino]-, cis-
• cis-4-[[[1-[(2S)-2-Carboxy-3-(2-methoxyethoxy)propyl]cyclopentyl]carbonyl]amino]cyclohexanecarboxylic acid
• Cyclohexanecarboxylic acid, 4-[[[1-[2-carboxy-3-(2-methoxyethoxy)propyl]cyclopentyl]carbonyl]amino]-, [4(S)-cis]-

Candoxatrilat

CAS: 123122-54-3

Candoxatrilat (U 73967, UK69578) is an active neutral endopeptidase inhibitor that reduces atrial natriuretic peptide degradation.

Formula: C₂₀H₃₃NO₇

Color and Shape: Solid

Molecular weight: 399.48

Ref: TM-T30701