CAS 1231929-97-7: Abemaciclib
Description:Abemaciclib is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), primarily used in the treatment of certain types of breast cancer, particularly hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. It functions by disrupting the cell cycle, thereby inhibiting cancer cell proliferation. Abemaciclib is administered orally and is characterized by its ability to penetrate tissues effectively, which contributes to its therapeutic efficacy. The substance has a molecular formula that reflects its complex structure, including multiple functional groups that enhance its binding affinity to the target kinases. Its pharmacokinetic profile indicates a moderate half-life, allowing for flexible dosing schedules. Common side effects associated with abemaciclib include diarrhea, fatigue, and neutropenia, necessitating regular monitoring of blood counts during treatment. Overall, abemaciclib represents a significant advancement in targeted cancer therapies, providing an option for patients with specific breast cancer subtypes.
Formula:C27H32F2N8
InChI:InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)
InChI key:InChIKey=UZWDCWONPYILKI-UHFFFAOYSA-N
SMILES:FC=1C=NC(=NC1C=2C=C(F)C=3N=C(N(C3C2)C(C)C)C)NC4=NC=C(C=C4)CN5CCN(CC)CC5
- Synonyms:
- 2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-
- Abemaciclib
- Ly 2835210
- Ly 2835219
- N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
- N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine
- Verzenio
- Verzenios
- LY2835219
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2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-
Ref: IN-DA000K5A
1g | 124.00 € | ||
5g | 270.00 € | ||
10g | 469.00 € | ||
100mg | 55.00 € | ||
250mg | 63.00 € |
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Abemaciclib
Controlled ProductRef: 86-MM3932.00-0250
250mg | 1,427.00 € |
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Abemaciclib
Ref: TM-T2381
5mg | 52.00 € | ||
10mg | 65.00 € | ||
25mg | 86.00 € | ||
50mg | 96.00 € | ||
100mg | 120.00 € | ||
200mg | 154.00 € | ||
500mg | 274.00 € |
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Abemaciclib
Controlled ProductRef: TR-A115153
10mg | 130.00 € | ||
50mg | 192.00 € | ||
100mg | 360.00 € |
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Abemaciclib
Ref: 3D-FE103812
1g | 732.00 € | ||
5g | 1,252.00 € | ||
10g | 1,878.00 € | ||
250mg | 334.00 € | ||
500mg | 461.00 € |