CAS 1231929-97-7
:Abemaciclib
Description:
Abemaciclib is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), primarily used in the treatment of certain types of breast cancer, particularly hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer. It functions by disrupting the cell cycle, thereby inhibiting cancer cell proliferation. Abemaciclib is administered orally and is characterized by its ability to penetrate tissues effectively, which contributes to its therapeutic efficacy. The substance has a molecular formula that reflects its complex structure, including multiple functional groups that enhance its binding affinity to the target kinases. Its pharmacokinetic profile indicates a moderate half-life, allowing for flexible dosing schedules. Common side effects associated with abemaciclib include diarrhea, fatigue, and neutropenia, necessitating regular monitoring of blood counts during treatment. Overall, abemaciclib represents a significant advancement in targeted cancer therapies, providing an option for patients with specific breast cancer subtypes.
Formula:C27H32F2N8
InChI:InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)
InChI key:InChIKey=UZWDCWONPYILKI-UHFFFAOYSA-N
SMILES:C(C)(C)N1C=2C(=C(F)C=C(C2)C3=NC(NC4=CC=C(CN5CCN(CC)CC5)C=N4)=NC=C3F)N=C1C
Synonyms:- 2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-
- Abemaciclib
- Ly 2835210
- Ly 2835219
- N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
- N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine
- Verzenio
- Verzenios
- LY2835219
- Bemaciclib(LY2835219free base
- Abemaciclib D10
- ethyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-amine
- abecilee
- LY 2835219 (free base)
- CDK4/6 dual inhibitor
- LY2835219free base,Abemaciclib
- Abemaciclib, >=98%
- LY2835219;LY-2835219;LY 2835219;ABEMACICLIB;CDK4/6 DUAL INHIBITOR;LY-2835219 FREE BASE
- LY2835219 (free base)
- N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-1,3-benzodiazol-5-yl)pyrimidin-2-amine
- Abemaciclib Powder
- CS-814
- Abemaciclib Mesylate (Verzenio)
- Abemaciclib free base
- LY-2835219 (free base)
- 5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine
- Abemaciclib (LY2835219)
- ABEMACICLIB BASE
- N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine
- Abemaciclib D7
- abemaciclib(CDK 4/6 inhibitor)
- inhibit,LY-2835219,LY 2835219,Abemaciclib,Inhibitor,Cyclin dependent kinase,CDK
- Bemaciclib(LY2835219, abemaciclib)
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 8 products.
N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-1,3-benzodiazol-5-yl)pyrimidin-2-amine
CAS:Formula:C27H32F2N8Purity:97%Color and Shape:SolidMolecular weight:506.5934Ref: IN-DA000K5A
1g65.00€5g170.00€10g307.00€50gTo inquire100gTo inquire100mg56.00€200mg59.00€250mg65.00€Abemaciclib
CAS:<p>Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.</p>Formula:C27H32F2N8Purity:99.43% - 99.87%Color and Shape:SolidMolecular weight:506.59Abemaciclib
CAS:<p>Inhibitor of cyclin-dependent kinases CDK4 and CDK6</p>Formula:C27H32F2N8Purity:Min. 95%Molecular weight:506.59 g/mol
![N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-1,3-be…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA000K5A.jpg&w=3840&q=75)
