CAS: 1231929-97-7 - LY2835219

Formula: C₂₇H₃₂F₂N₈

InChI: InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)

InChI key: InChIKey=UZWDCWONPYILKI-UHFFFAOYSA-N

SMILES: FC=1C=NC(=NC1C=2C=C(F)C=3N=C(N(C3C2)C(C)C)C)NC4=NC=C(C=C4)CN5CCN(CC)CC5

Synonyms:

• 2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-
• Abemaciclib
• Ly 2835210
• Ly 2835219
• N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine
• N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine
• Verzenio
• Verzenios

2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-

CAS: 1231929-97-7

• Formula: C₂₇H₃₂F₂N₈
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 506.5934

Abemaciclib Mesylate

CAS: 1231929-97-71231930-82-7

• Formula: C₂₇H₃₂F₂N₈·CH₄O₃S
• Color and Shape: White To Off-White Solid
• Molecular weight: 506.61 96.10

Abemaciclib

CAS: 1231929-97-7

• Formula: C₂₇H₃₂F₂N₈
• Color and Shape: Neat
• Molecular weight: 506.59

Abemaciclib

CAS: 1231929-97-7

Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.

• Formula: C₂₇H₃₂F₂N₈
• Purity: 99.39% - 99.87%
• Color and Shape: Solid
• Molecular weight: 506.59

Abemaciclib

CAS: 1231929-97-7

• Formula: C₂₇H₃₂F₂N₈
• Color and Shape: Neat
• Molecular weight: 506.59

Abemaciclib

CAS: 1231929-97-7

Inhibitor of cyclin-dependent kinases CDK4 and CDK6

• Formula: C₂₇H₃₂F₂N₈
• Purity: Min. 95%
• Molecular weight: 506.59 g/mol