CAS 1231930-82-7

Bamaciclib Mesylate

Description:

Bamaciclib mesylate is a small molecule inhibitor primarily targeting cyclin-dependent kinases (CDKs), specifically CDK4 and CDK6, which play crucial roles in cell cycle regulation. This compound is utilized in the treatment of certain types of cancers, particularly hormone receptor-positive breast cancer, by inhibiting the proliferation of cancer cells. Bamaciclib mesylate is characterized by its ability to disrupt the cell cycle, leading to cell cycle arrest and apoptosis in malignant cells. The mesylate salt form enhances its solubility and bioavailability, making it more effective for therapeutic use. In terms of physical properties, it is typically presented as a white to off-white solid. The compound's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are essential for determining its efficacy and safety profile in clinical settings. As with many targeted therapies, monitoring for potential side effects and drug interactions is crucial during treatment. Overall, Bamaciclib mesylate represents a significant advancement in targeted cancer therapies, contributing to personalized medicine approaches in oncology.

Synonyms:

• Abemaciclib Mesylate

2-​Pyrimidinamine, N-​[5-​[(4-​ethyl-​1-​piperazinyl)​methyl]​-​2-​pyridinyl]​-​5-​fluoro-​4-​[4-​fluoro-​2-​methyl-​1-​(1-​methylethyl)​-​1H-​benzimidazol-​6-​yl]​-​, methanesulfonate (1:1)

CAS: 1231930-82-7

Formula: C₂₈H₃₆F₂N₈O₃S

Purity: 95%

Color and Shape: Solid

Molecular weight: 602.6990

Ref: IN-DA000K54

Abemaciclib Mesylate

CAS: 1231930-82-7

Formula: C₂₇H₃₂F₂N₈·CH₄O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 506.61 96.10

Ref: 4Z-A-253001

Abemaciclib methanesulfonate

CAS: 1231930-82-7

Abemaciclib methanesulfonate

Purity: ≥98%

Molecular weight: 602.7g/mol

Ref: 54-BUP15077

N-(5-((4-Ethylpiperazin-1-Yl)Methyl)Pyridin-2-Yl)-5-Fluoro-4-(4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[d]Imidazol-6-Yl)Pyrimidin-2-Amine Methanesulfonate

CAS: 1231930-82-7

N-(5-((4-Ethylpiperazin-1-Yl)Methyl)Pyridin-2-Yl)-5-Fluoro-4-(4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[d]Imidazol-6-Yl)Pyrimidin-2-Amine Methanesulfonate

Purity: 98%

Molecular weight: 602.7g/mol

Ref: 54-PC109072

LY2835219

CAS: 1231930-82-7

Ref: 7W-GW8945

Abemaciclib methanesulfonate

CAS: 1231930-82-7

Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).

Formula: C₂₇H₃₂F₂N₈·CH₄O₃S

Purity: 98.69% - 99.44%

Color and Shape: Solid

Molecular weight: 602.7

Ref: TM-T3111

Abemaciclib mesylate

CAS: 1231930-82-7

Inhibits cyclin-dependent kinase 4 and 6 (CDK4 and CDK6); antineoplastic

Formula: C₂₇H₃₂F₂N₈•CH₄O₃S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 602.7 g/mol

Ref: 3D-FA159696

Abemaciclib Mesylate

CAS: 1231930-82-7

Formula: C₂₇H₃₂F₂N₈CH₄O₃S

Molecular weight: 506.61 : 96.10

Ref: ST-EA-CP-A97016