CAS 1232410-49-9

VE-821

Description:

VE-821, with the CAS number 1232410-49-9, is a small molecule that functions primarily as a selective inhibitor of the enzyme ATR (Ataxia Telangiectasia and Rad3 related protein). This compound has garnered attention in the field of cancer research due to its potential to enhance the efficacy of certain chemotherapeutic agents by targeting the DNA damage response pathways. VE-821 exhibits characteristics such as a relatively low molecular weight and specific structural features that facilitate its interaction with the ATR protein. Its selectivity for ATR over other kinases is significant, as it minimizes off-target effects, making it a valuable tool in both preclinical and clinical studies. Additionally, VE-821 has been investigated for its role in sensitizing cancer cells to radiation and other DNA-damaging agents, thereby contributing to the development of combination therapies aimed at improving treatment outcomes in various malignancies. As research continues, the full therapeutic potential and mechanisms of action of VE-821 are being explored further.

3-Amino-6-(4-methanesulfonylphenyl)-N-phenylpyrazine-2-carboxamide

CAS: 1232410-49-9

Formula: C₁₈H₁₆N₄O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 368.4096

Ref: IN-DA000K81

VE-821

CAS: 1232410-49-9

VE-821

Purity: ≥95%

Molecular weight: 368.41g/mol

Ref: 54-BUP05875

VE-821

CAS: 1232410-49-9

VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).

Formula: C₁₈H₁₆N₄O₃S

Purity: 97.19% - 99.97%

Color and Shape: Solid

Molecular weight: 368.41

Ref: TM-T3032

VE-821

CAS: 1232410-49-9

Formula: C₁₈H₁₆N₄O₃S

Molecular weight: 368.41

Ref: 4Z-K-031030

VE-821

CAS: 1232410-49-9

Formula: C₁₈H₁₆N₄O₃S

Purity: 95.0%

Molecular weight: 368.41

Ref: 10-F332541

VE 821

Controlled Product

CAS: 1232410-49-9

Applications VE 821 is a potent and selective inhibitor of DNA damage response kinase, ATR. VE 821 functions to disrupt DNA damage repair system of tumor cells, limiting their abilities for further growth.
References Finlay, M., et al.: Bioorg. Medn. Chem. Letters., 22, 5352 (2012);

Formula: C₁₈H₁₆N₄O₃S

Color and Shape: Neat

Molecular weight: 368.41

Ref: TR-V756700

VE 821

CAS: 1232410-49-9

VE 821 is a chemical inhibitor that inhibits the activity of the protein ornithine decarboxylase (ODC). This enzyme is essential for the synthesis of polyamines, which are essential for cell growth. VE 821 has been shown to be effective in inhibiting the growth of solid tumours and leukemia cells. It also inhibits the production of DNA, RNA, and proteins by cells. VE 821 has minimal toxicity to healthy cells, and has been shown to work synergistically with other pharmacological agents such as radiation therapy.

Formula: C₁₈H₁₆N₄O₃S

Purity: Min. 95%

Molecular weight: 368.41 g/mol

Ref: 3D-BV168070