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CAS 123246-29-7

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ganirelix

Description:
Ganirelix is a synthetic peptide that functions as a gonadotropin-releasing hormone (GnRH) antagonist. It is primarily used in assisted reproductive technology to prevent premature ovulation during controlled ovarian stimulation. The substance is characterized by its ability to competitively inhibit the action of GnRH at the pituitary gland, thereby reducing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This mechanism helps in controlling the timing of ovulation, which is crucial for successful fertility treatments. Ganirelix is typically administered via subcutaneous injection and is known for its relatively short half-life, necessitating careful dosing schedules. The compound is generally well-tolerated, though some patients may experience side effects such as injection site reactions or hormonal fluctuations. Its chemical structure includes a sequence of amino acids that contribute to its biological activity and specificity for the GnRH receptor. Overall, ganirelix plays a significant role in reproductive medicine, aiding in the management of fertility treatments.
Formula:C80H113ClN18O13
InChI:InChI=1/C80H113ClN18O13/c1-9-84-79(85-10-2)88-39-17-15-27-60(70(104)94-62(42-49(5)6)71(105)93-61(28-16-18-40-89-80(86-11-3)87-12-4)78(112)99-41-21-29-68(99)77(111)90-50(7)69(82)103)92-72(106)63(44-53-32-36-58(102)37-33-53)97-76(110)67(48-100)98-74(108)65(45-54-22-20-38-83-47-54)96-73(107)64(43-52-30-34-57(81)35-31-52)95-75(109)66(91-51(8)101)46-56-25-19-24-55-23-13-14-26-59(55)56/h13-14,19-20,22-26,30-38,47,49-50,60-68,100,102H,9-12,15-18,21,27-29,39-46,48H2,1-8H3,(H2,82,103)(H,90,111)(H,91,101)(H,92,106)(H,93,105)(H,94,104)(H,95,109)(H,96,107)(H,97,110)(H,98,108)(H2,84,85,88)(H2,86,87,89)/t50-,60-,61+,62+,63+,64-,65-,66-,67+,68+/m1/s1
Synonyms:
  • N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide
  • Orgalutran
  • Rs 26306
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