CAS 123276-94-8

Apidaecin Ib (9CI)

Description:

Apidaecin Ib (9CI) is a peptide antibiotic derived from honeybee (Apis mellifera) venom, specifically known for its antimicrobial properties. It belongs to a class of compounds called defensins, which are small, cationic peptides that play a crucial role in the innate immune response of various organisms. Apidaecin Ib exhibits a broad spectrum of activity against Gram-negative bacteria, making it a subject of interest for potential therapeutic applications, particularly in combating antibiotic-resistant strains. The structure of Apidaecin Ib features a unique arrangement of amino acids that contributes to its ability to disrupt bacterial cell membranes, leading to cell lysis. Additionally, it is characterized by its stability in various environmental conditions, which enhances its potential for use in pharmaceutical formulations. Research into Apidaecin Ib continues to explore its mechanisms of action, efficacy, and potential applications in medicine, particularly in the development of new antimicrobial agents.

Formula: C₉₅H₁₅₀N₃₂O₂₃

Synonyms:

• ApidaecinIa, 18-L-leucine-
• 101: PN: WO0031279 TABLE: 1 unclaimed protein
• 2: PN:WO2009013262 SEQID: 2 claimed protein
• 30: PN: WO2008058016 SEQID: 30 claimedprotein
• 5: PN: US20020035061TABLE: 1 unclaimed protein
• Apidaecin 1b
• Apidaecin HbIb (honey bee)
• L-Leucine,glycyl-L-asparaginyl-L-asparaginyl-L-arginyl-L-prolyl-L-valyl-L-tyrosyl-L-isoleucyl-L-prolyl-L-glutaminyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-histidyl-L-prolyl-L-arginyl-
• 686: PN: US20050058603 SEQID: 680 claimed sequence
• 5: PN: CN1807645 SEQID: 5 unclaimed sequence

Apidaecin IB

CAS: 123276-94-8

Apidaecin IB is an insect antimicrobial peptide, with MIC values of 8 μM for E. coli (O18K1H7, ML35 and ATCC 25922).

Formula: C₉₅H₁₅₀N₃₂O₂₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 2108.446

Ref: TM-T10347