CAS 123319-03-9

1-Oxa-8-azaspiro[4.5]decan-3-one,2,8-dimethyl-

Description:

1-Oxa-8-azaspiro[4.5]decan-3-one, 2,8-dimethyl- is a chemical compound characterized by its unique spirocyclic structure, which includes both an oxygen and a nitrogen atom within its framework. The presence of the spiro system indicates that the molecule contains two rings that share a single atom, contributing to its rigidity and potential biological activity. The dimethyl groups at the 2 and 8 positions suggest that the compound may exhibit specific steric and electronic properties, influencing its reactivity and interactions with biological targets. This compound may be of interest in medicinal chemistry due to its structural features, which could lead to the development of novel pharmaceuticals. Additionally, the presence of the ketone functional group at the 3-position may enhance its reactivity, allowing for further chemical modifications. Overall, 1-Oxa-8-azaspiro[4.5]decan-3-one, 2,8-dimethyl- represents a class of compounds that could have diverse applications in drug discovery and development.

Formula: C₁₀H₁₇NO₂

Synonyms:

• Arl 14995
• OODDNJQTVFMGCF-UHFFFAOYSA-N

ARL 14495

Controlled Product

CAS: 123319-03-9

Applications ARL 14495 is a rigid M1/M3 muscarinic agonist affecting acetylcholine activity, used often in the treatment of Alzheimer’s disease.
References Wu, E. et al.: J. Med, Chem., 41, 4181 (1998); Lucini, L. et al.: Sci. Horticult., 182, 124 (2015);

Formula: C₁₀H₁₇NO₂

Color and Shape: Neat

Molecular weight: 183.248

Ref: TR-A771480

ARL 14495

CAS: 123319-03-9

ARL 14495 is a research tool for studying the interactions between proteins and ligands. ARL 14495 is a high-purity, small-molecule activator of G protein-coupled receptors (GPCRs). The activation of GPCRs by ARL 14495 leads to the opening of ion channels and an influx of ions into cells. It also activates phospholipase C, leading to increased levels of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 causes the release of calcium from intracellular stores, while DAG activates protein kinase C. ARL 14495 also inhibits adenylyl cyclase activity, which decreases cAMP levels and has effects on other signaling molecules such as nitric oxide synthase.
ARL14495 has been shown to inhibit the activity of ion channels such as Na+, K+, Ca2+ and Cl− in various types of cells

Formula: C₁₀H₁₇NO₂

Purity: Min. 95%

Molecular weight: 183.25 g/mol

Ref: 3D-YEA31903