CAS 123372-13-4

(S)-(-)-O-DESMETHYLCARVEDILOL

Description:

(S)-(-)-O-Desmethycarvedilol is a chiral compound that is a derivative of carvedilol, a medication primarily used to treat hypertension and heart failure. This substance exhibits both alpha- and beta-adrenergic blocking properties, contributing to its cardiovascular effects. As a selective antagonist, it helps in reducing heart rate and lowering blood pressure. The compound's stereochemistry is significant, as the (S)-(-) configuration is associated with specific pharmacological activity and efficacy. In terms of physical properties, it is typically a solid at room temperature and may exhibit solubility in organic solvents, while its solubility in water can vary. The compound's mechanism of action involves the inhibition of certain neurotransmitters, leading to vasodilation and improved cardiac output. Additionally, it may possess antioxidant properties, which can further benefit cardiovascular health. As with many pharmaceuticals, the safety profile and potential side effects are important considerations in its therapeutic use. Overall, (S)-(-)-O-Desmethycarvedilol represents a significant compound in the realm of cardiovascular pharmacotherapy.

Formula: C₂₃H₂₄N₂O₄

InChI: InChI=1/C23H24N2O4/c26-16(14-24-12-13-28-21-10-4-3-9-20(21)27)15-29-22-11-5-8-19-23(22)17-6-1-2-7-18(17)25-19/h1-11,16,24-27H,12-15H2/t16-/m1/s1

SMILES: c1ccc2c(c1)c1c(cccc1OC[C@@H](CNCCOc1ccccc1O)O)[nH]2

Synonyms:

• (S)-(-)-Desmethyl Carvedilol
• (S)- 2-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]phenol

Phenol, 2-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-, (S)- (9CI)

CAS: 123372-13-4

Formula: C₂₃H₂₄N₂O₄

Color and Shape: Solid

Molecular weight: 392.4477

Ref: IN-DA000KHB

(S)-(-)-O-Desmethyl Carvedilol

CAS: 123372-13-4

Formula: C₂₃H₂₄N₂O₄

Molecular weight: 392.46

Ref: 4Z-C-0249

(S)-(-)-O-Desmethyl Carvedilol

Controlled Product

CAS: 123372-13-4

Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity. [α]D= -18.7 (c= 0.1 methanol)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),

Formula: C₂₃H₂₄N₂O₄

Color and Shape: Neat

Molecular weight: 392.45

Ref: TR-D291485