CAS 1234423-95-0

17-[[[3-[(4S)-6,8-Dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide

Description:

The chemical substance with the name "17-[[[3-[(4S)-6,8-Dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide" and CAS number "1234423-95-0" is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups such as sulfonamides, amides, and oxo groups. The presence of dichloro and tetrahydroisoquinoline moieties suggests potential biological activity, possibly as a pharmaceutical agent. Its long carbon chain and multiple ether linkages indicate a degree of hydrophilicity, which may influence its solubility and bioavailability. The compound's structural complexity may also suggest specific interactions with biological targets, making it of interest in medicinal chemistry. However, detailed studies would be necessary to elucidate its properties, including stability, reactivity, and potential therapeutic applications.

Formula: C₅₀H₆₆Cl₄N₈O₁₀S₂

InChI: InChI=1S/C50H66Cl4N8O10S2/c1-61-31-43(41-27-37(51)29-47(53)45(41)33-61)35-7-5-9-39(25-35)73(65,66)59-15-19-71-23-21-69-17-13-57-49(63)55-11-3-4-12-56-50(64)58-14-18-70-22-24-72-20-16-60-74(67,68)40-10-6-8-36(26-40)44-32-62(2)34-46-42(44)28-38(52)30-48(46)54/h5-10,25-30,43-44,59-60H,3-4,11-24,31-34H2,1-2H3,(H2,55,57,63)(H2,56,58,64)/t43-,44-/m0/s1

InChI key: InChIKey=DNHPDWGIXIMXSA-CXNSMIOJSA-N

SMILES: ClC1=C2C([C@@H](CN(C)C2)C3=CC(S(NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNS(=O)(=O)C4=CC(=CC=C4)[C@H]5C=6C(=C(Cl)C=C(Cl)C6)CN(C)C5)=O)=O)(=O)=O)=CC=C3)=CC(Cl)=C1

Synonyms:

• 17-[[[3-[(4S)-6,8-Dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide
• Ibsrela
• AZD 1722
• Tenapanor
• 12,15-Dioxa-2,7,9-triazaheptadecanamide, 17-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-

Tenapanor

CAS: 1234423-95-0

Tenapanor

Purity: ≥98%

Molecular weight: 1145.05g/mol

Ref: 54-BUP07081

Tenapanor

CAS: 1234423-95-0

Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.

Formula: C₅₀H₆₆Cl₄N₈O₁₀S₂

Purity: 99.49% - 99.85%

Color and Shape: Solid

Molecular weight: 1145.05

Ref: TM-T7587

Tenapanor

CAS: 1234423-95-0

Tenapanor is a novel antidiabetic drug that has been shown to be effective in the treatment of type 2 diabetes. Tenapanor (INN) reduces blood glucose levels by stimulating insulin release from pancreatic beta-cells and increasing insulin sensitivity in peripheral tissues. Tenapanor binds to the ATP-binding site of the phosphoinositide 3-kinase-related protein kinase 1 (PI3K1) enzyme, which is involved in glucose metabolism. It also inhibits phosphodiesterase 4D (PDE4D), an enzyme that degrades cyclic adenosine monophosphate (cAMP). This dual mechanism of action leads to increased insulin secretion and increased insulin sensitivity, which results in improved glycemic control.
Tenapanor has also been shown to improve long-term efficacy and reduce hypoglycemia when used as a pharmacological treatment for type 2 diabetes. The agent binds to ATP-binding sites on PI3K1, which prevents its

Formula: C₅₀H₆₆Cl₄N₈O₁₀S₂

Purity: Min. 95%

Molecular weight: 1,145.04 g/mol

Ref: 3D-BT178667

Tenapanor (Butylene-D8)

Controlled Product

CAS: 1234423-95-0

Formula: C₅₀D₈H₅₈Cl₄N₈O₁₀S₂

Color and Shape: Neat

Molecular weight: 1153.098

Ref: TR-D436897

Tenapanor

Controlled Product

CAS: 1234423-95-0

Formula: C₅₀H₆₆Cl₄N₈O₁₀S₂

Color and Shape: Neat

Molecular weight: 1145.049

Ref: TR-T123440