CAS 123447-62-1

Prulifloxacin

Description:

Prulifloxacin is a synthetic fluoroquinolone antibiotic, primarily used for the treatment of bacterial infections. It exhibits broad-spectrum antibacterial activity, particularly against Gram-negative and some Gram-positive bacteria. The compound functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Prulifloxacin is characterized by its relatively high oral bioavailability and is often administered in its prodrug form, which is converted into its active metabolite in the body. This antibiotic is known for its favorable pharmacokinetic properties, including a moderate half-life, allowing for once-daily dosing in many cases. Additionally, it has been noted for its lower propensity to cause certain side effects commonly associated with other fluoroquinolones, such as tendon damage. However, like all antibiotics, its use should be guided by susceptibility patterns to minimize the risk of resistance development. Overall, Prulifloxacin represents a valuable option in the antibiotic arsenal, particularly for treating urinary tract infections and other susceptible bacterial infections.

Formula: C₂₁H₂₀FN₃O₆S

InChI: InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)

InChI key: InChIKey=PWNMXPDKBYZCOO-UHFFFAOYSA-N

SMILES: CC1N2C=3C(C(=O)C(C(O)=O)=C2S1)=CC(F)=C(C3)N4CCN(CC5=C(C)OC(=O)O5)CC4

Synonyms:

• (+/-)-7-{4-[(Z)-2,3-Dihydroxy-2-Butenyl]-1-Piperazinyl}-6-Fluoro-1-Methyl-4-Oxo-1H,4H-[1,3]Thiazeto[3,2-A]Quinoline-3-Carboxylic Acid Cyclic Carbonate
• (1R)-6-fluoro-1-methyl-7-{4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]piperazin-1-yl}-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
• 1,3-Dioxole, 1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid deriv.
• 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-
• 6-Fluoro-1-Methyl-7-(4-(5-Methyl-2-Oxo-1,3-Dioxelen-4-Yl)Methyl-1-Piperazinyl)-4-Oxo-4H-(1,3)Thiazeto(3,2-A)Quinoline-3-Carboxylic Acid
• 6-Fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
• 6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]piperazin-1-yl]-4-oxo-2a,3-dihydro-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
• 6-fluoro-1-methyl-7-{4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]piperazin-1-yl}-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
• Nm 441
• Quisnon
• Sword

Prulifloxacin

CAS: 123447-62-1

Formula: C₂₁H₂₀FN₃O₆S

Purity: >98.0%(T)(HPLC)

Color and Shape: Light orange to Yellow to Green powder to crystal

Molecular weight: 461.46

Ref: 3B-P2058

1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-

CAS: 123447-62-1

Formula: C₂₁H₂₀FN₃O₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 461.4634

Ref: IN-DA000KL9

Prulifloxacin

CAS: 123447-62-1

Prulifloxacin

Purity: ≥98%

Molecular weight: 461.46g/mol

Ref: 54-BUP17215

Prulifloxacin

CAS: 123447-62-1

Formula: C₂₁H₂₀FN₃O₆S

Color and Shape: White To Off-White Solid

Molecular weight: 461.47

Ref: 4Z-P-421

Prulifloxacin-d8

CAS: 123447-62-1

Formula: C₂₁H₁₂FN₃O₆SD₈

Molecular weight: 469.52

Ref: 4Z-P-422

Prulifloxacin

CAS: 123447-62-1

Molecular weight: 461.5

Ref: 7W-GA1815

Prulifloxacin

CAS: 123447-62-1

Prulifloxacin

Purity: 98%

Molecular weight: 461.46g/mol

Ref: 54-PC109254

Prulifloxacin

CAS: 123447-62-1

Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.

Formula: C₂₁H₂₀FN₃O₆S

Purity: 99.47%

Color and Shape: Yellow Or Slightly Yellow Power

Molecular weight: 461.46

Ref: TM-T5394

Prulifloxacin

CAS: 123447-62-1

Applications Prulifloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Prulifloxacin is a prodrug for active metabolite, Ulifloxacin. Antibacterial.
References Ozaki, M., et al.: Antimicrob. Agents Chemother., 35, 2496 (1991), Segawa, J., et al.: J. Med. Chem., 35, 4727 (1992), Nakashima, M., et al.: J. Clin. Pharmacol., 34, 930 (1994),

Formula: C₂₁H₂₀FN₃O₆S

Color and Shape: Neat

Molecular weight: 461.46

Ref: TR-P838885

Prulifloxacin

CAS: 123447-62-1

Prulifloxacin is a fluoroquinolone antibiotic with action on bacterial DNA gyrase and topoisomerase IV and is used for treating urinary tract infections and respiratory infections.

Formula: C₂₁H₂₀FN₃O₆S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 461.46 g/mol

Ref: 3D-AP27249

Prulifloxacin

CAS: 123447-62-1

Purity: 98%(HPLC);RG

Molecular weight: 461.4599915

Ref: 10-F876131