CAS 123524-52-7: Azelnidipine
Description:Azelnidipine is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of compounds, which are characterized by their ability to inhibit calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation and a subsequent reduction in blood pressure. Azelnidipine is known for its long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound exhibits selectivity for vascular tissues over cardiac tissues, minimizing potential side effects such as reflex tachycardia. Additionally, it has antioxidant properties, which may provide additional cardiovascular benefits. Azelnidipine is typically administered in its hydrochloride salt form and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics can be influenced by food intake, and it is metabolized primarily in the liver. Overall, Azelnidipine represents a valuable option in antihypertensive therapy, particularly for patients requiring long-term management of high blood pressure.
Formula:C33H34N4O6
InChI:InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
InChI key:InChIKey=ZKFQEACEUNWPMT-UHFFFAOYSA-N
SMILES:O=C(OC(C)C)C1=C(NC(N)=C(C(=O)OC2CN(C2)C(C=3C=CC=CC3)C=4C=CC=CC4)C1C=5C=CC=C(C5)N(=O)=O)C
- Synonyms:
- 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)-
- 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
- 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
- 3-O-(1-Benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 3-[1-(Diphenylmethyl)Azetidin-3-Yl] 5-Propan-2-Yl 2-Amino-6-Methyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
- Calblock
- Ccris 8650
- Cs 905
- See more synonyms
- Unii-Pv23P19Yug
- Azelnidipine