CAS 123524-52-7

Azelnidipine

Description:

Azelnidipine is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of compounds, which are characterized by their ability to inhibit calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation and a subsequent reduction in blood pressure. Azelnidipine is known for its long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound exhibits selectivity for vascular tissues over cardiac tissues, minimizing potential side effects such as reflex tachycardia. Additionally, it has antioxidant properties, which may provide additional cardiovascular benefits. Azelnidipine is typically administered in its hydrochloride salt form and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics can be influenced by food intake, and it is metabolized primarily in the liver. Overall, Azelnidipine represents a valuable option in antihypertensive therapy, particularly for patients requiring long-term management of high blood pressure.

Formula: C₃₃H₃₄N₄O₆

InChI: InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3

InChI key: InChIKey=ZKFQEACEUNWPMT-UHFFFAOYSA-N

SMILES: C(OC1CN(C(C2=CC=CC=C2)C3=CC=CC=C3)C1)(=O)C=4C(C(C(OC(C)C)=O)=C(C)NC4N)C5=CC(N(=O)=O)=CC=C5

Synonyms:

• 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)-
• 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
• 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• 3-O-(1-Benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3-[1-(Diphenylmethyl)Azetidin-3-Yl] 5-Propan-2-Yl 2-Amino-6-Methyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• Calblock
• Ccris 8650
• Cs 905
• Unii-Pv23P19Yug

3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester

CAS: 123524-52-7

Formula: C₃₃H₃₄N₄O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 582.6463

Ref: IN-DA000KQ9

Azelnidipine

CAS: 123524-52-7

Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.

Formula: C₃₃H₃₄N₄O₆

Purity: 99.78%

Color and Shape: Light Yellowish Powder

Molecular weight: 582.65

Ref: TM-T0121

Azelnidipine

CAS: 123524-52-7

Formula: C₃₃H₃₄N₄O₆

Color and Shape: Light Yellow Solid

Molecular weight: 582.66

Ref: 4Z-A-10101

Azelnidipine

CAS: 123524-52-7

Azelnidipine

Purity: ≥98%

Molecular weight: 582.65g/mol

Ref: 54-BUP13584

Azelnidipine

CAS: 123524-52-7

Azelnidipine

Purity: 99%

Molecular weight: 582.65g/mol

Ref: 54-OR1028132

Azelnidipine-d7

CAS: 123524-52-7

Formula: C₃₃H₂₇D₇N₄O₆

Color and Shape: Yellow Solid

Molecular weight: 589.70

Ref: 4Z-A-10102

Azelnidipine

CAS: 123524-52-7

Formula: C₃₃H₃₄N₄O₆

Purity: >98.0%(T)(HPLC)

Color and Shape: Light orange to Yellow to Green powder to crystal

Molecular weight: 582.66

Ref: 3B-A2433

Azelnidipine

CAS: 123524-52-7

Formula: C₃₃H₃₄N₄O₆

Purity: (HPLC) ≥ 98.0%

Color and Shape: Off-white to light yellow powder

Molecular weight: 582.65

Ref: 7W-GP5829

Azelnidipine

CAS: 123524-52-7

Azelnidipine is a drug that is used to treat high blood pressure and heart disease. It reduces the risk of cardiovascular events such as myocardial infarction and stroke. Azelnidipine has been shown to have an antioxidative effect, which may be due to its ability to decrease lipid peroxidation, increase superoxide dismutase activity, and inhibit the production of reactive oxygen species in a model of tubulointerstitial injury. The drug also inhibits calcium influx into cells by interfering with voltage-gated calcium channels. Azelnidipine binds reversibly to α1-acid glycoprotein, which is found in plasma and erythrocytes. This interaction may result in changes in renal function when combined with other drugs that bind the same protein (e.g., warfarin).

Formula: C₃₃H₃₄N₄O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 582.65 g/mol

Ref: 3D-FA18072

Azelnidipine

Controlled Product

CAS: 123524-52-7

Applications Azelnidipine is a dihydropyridine calcium channel blocker with antihypertensice activity. Azelnidipine is used for treating ischemic heart disease and cardiac remodeling after myocardial infarction. Studies show that Azelnidipine ttreatment can reduce the risk of hyperglycemia induced metabolic disorders
References Sugimoto, K. et al.: Int. J. Hypertens., No pp. (2010); Kain, V. et al.: Cardio. Diabetol., 9, 82 (2010); Kinouchi, K. et al.: Int. J. Hypertens., 284823, 11 (2011);

Formula: C₃₃H₃₄N₄O₆

Color and Shape: Yellow

Molecular weight: 582.65

Ref: TR-A808500