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Azelnidipine

CAS 123524-52-7: Azelnidipine

Description:Azelnidipine is a calcium channel blocker primarily used in the treatment of hypertension. It belongs to the dihydropyridine class of compounds, which are characterized by their ability to inhibit calcium influx through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation and a subsequent reduction in blood pressure. Azelnidipine is known for its long half-life, allowing for once-daily dosing, which enhances patient compliance. The compound exhibits selectivity for vascular tissues over cardiac tissues, minimizing potential side effects such as reflex tachycardia. Additionally, it has antioxidant properties, which may provide additional cardiovascular benefits. Azelnidipine is typically administered in its hydrochloride salt form and is well-absorbed in the gastrointestinal tract. Its pharmacokinetics can be influenced by food intake, and it is metabolized primarily in the liver. Overall, Azelnidipine represents a valuable option in antihypertensive therapy, particularly for patients requiring long-term management of high blood pressure.

Formula:C33H34N4O6

InChI:InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3

InChI key:InChIKey=ZKFQEACEUNWPMT-UHFFFAOYSA-N

SMILES:O=C(OC(C)C)C1=C(NC(N)=C(C(=O)OC2CN(C2)C(C=3C=CC=CC3)C=4C=CC=CC4)C1C=5C=CC=C(C5)N(=O)=O)C

  • Synonyms:
  • 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)-
  • 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
  • 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
  • 3-O-(1-Benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 3-[1-(Diphenylmethyl)Azetidin-3-Yl] 5-Propan-2-Yl 2-Amino-6-Methyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
  • Calblock
  • Ccris 8650
  • Cs 905
  • See more synonyms
  • Unii-Pv23P19Yug
  • Azelnidipine
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Found 8 products.

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Azelnidipine

CAS:123524-52-7

Ref: TM-T0121

5mg50.00 €
10mg67.00 €
25mg109.00 €
50mg172.00 €
100mg309.00 €
200mg500.00 €
500mg800.00 €
1mL*10mM (DMSO)74.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
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Azelnidipine-d7

CAS:123524-52-7

Ref: 4Z-A-10102

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Thursday 6 Mar 2025
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Azelnidipine

CAS:123524-52-7

Ref: 4Z-A-10101

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Thursday 6 Mar 2025
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Azelnidipine

CAS:123524-52-7

Ref: 3B-A2433

1g65.00 €
5g199.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
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Azelnidipine

CAS:123524-52-7

Ref: 7W-GP5829

100mg99.00 €
Estimated delivery in United States, on Wednesday 12 Mar 2025
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Azelnidipine

CAS:123524-52-7

Ref: 3D-FA18072

5g147.00 €
10g207.00 €
Estimated delivery in United States, on Tuesday 18 Mar 2025
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Azelnidipine

Controlled Product
CAS:123524-52-7

Ref: TR-A808500

1g244.00 €
10mg97.00 €
Estimated delivery in United States, on Tuesday 15 Apr 2025
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