CAS 1236-00-6

10β-Hydroxy-19-norethisterone

Description:

10β-Hydroxy-19-norethisterone, also known as 10β-hydroxy-19-norprogesterone, is a synthetic progestin that belongs to the class of steroid hormones. It is characterized by its structural modifications that enhance its progestational activity, making it effective in various therapeutic applications, particularly in hormone replacement therapy and contraceptive formulations. The compound features a cyclopentanoperhydrophenanthrene core typical of steroid structures, with specific hydroxyl and keto functional groups that influence its biological activity and receptor binding affinity. Its chemical formula reflects the presence of carbon, hydrogen, and oxygen atoms, contributing to its lipophilicity and metabolic stability. 10β-Hydroxy-19-norethisterone exhibits a range of pharmacological effects, including the regulation of menstrual cycles and the inhibition of ovulation. As with many synthetic hormones, its use may be associated with side effects, and its safety profile is evaluated in clinical contexts. The compound is also of interest in research settings for its potential applications in reproductive health and endocrinology.

Formula: C₂₀H₂₆O₃

InChI: InChI=1/C20H26O3/c1-3-19(22)10-8-16-15-5-4-13-12-14(21)6-11-20(13,23)17(15)7-9-18(16,19)2/h1,12,15-17,22-23H,4-11H2,2H3/t15-,16-,17-,18-,19-,20+/m0/s1

InChI key: InChIKey=GYRPICHNIDQFOD-RPZLJYRGSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(O)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@]2(C#C)O)[H]

Synonyms:

• (17α)-10,17-Dihydroxy-19-norpregn-4-en-20-yn-3-one
• 10β,17-Dihydroxy-19-nor-17α-pregn-4-en-20-yn-3-one
• 10β,17β-Dihydroxy-17α-ethynylestr-4-en-3-one
• 10β-Hydroxy-19-norethisterone
• 10β-Hydroxynorethindrone
• 10β-Hydroxynorethisterone
• 17-Ethynyl-10-hydroxy-19-nortestosterone
• 17α-Ethinyl-10β,17β-dihydroxyestr-4-en-3-one
• 17α-Ethynyl-10β,17β-dihydroxy-4-estren-3-one
• 19-Nor-17.alpha.-pregn-4-en-20-yn-3-one, 10,17-dihydroxy-
• 19-Nor-17alpha-pregn-4-en-20-yn-3-one, 10,17-dihydroxy-
• 19-Nor-17α-pregn-4-en-20-yn-3-one, 10,17-dihydroxy-
• 19-Norpregn-4-en-20-yn-3-one, 10,17-dihydroxy-, (17.alpha.)-
• 19-Norpregn-4-en-20-yn-3-one, 10,17-dihydroxy-, (17alpha)-
• 19-Norpregn-4-en-20-yn-3-one, 10,17-dihydroxy-, (17α)-
• 19-Nortestosterone, 17-ethynyl-10-hydroxy-
• Estr-4-en-3-one, 17.alpha.-ethynyl-10,17-dihydroxy
• Estr-4-en-3-one, 17alpha-ethynyl-10,17-dihydroxy
• NSC 63012
• 10,17-Dihydroxy-19-nor-17α-pregn-4-en-20-yn-3-one
• 10,17-.alpha.-Dihydroxy-19-norpregn-4-en-20-yn-3-one
• Norethindrone 10-Hydroxy Impurity
• 10.beta.Hydroxynorethisterone
• 10β-Hydroxy Norethindrone
• 10-.beta.-Hydroxynorethisterone
• 17-.alpha.-Ethynyl-10-.beta.-17-.beta.-dihydroxy-4-estren-3-one

Norethindrone Impurity 25 (10-β Hydroxy Norethindrone)

CAS: 1236-00-6

Formula: C₂₀H₂₆O₃

Color and Shape: White To Off-White Solid

Molecular weight: 314.43

Ref: 4Z-N-2917

10β-Hydroxy Norethindrone

Controlled Product

CAS: 1236-00-6

Applications 10β-Hydroxynorethindrone is the 6β-hydroxy analogue and a by-product of Norethindrone (N676000) synthesis. 10β-Hydroxynorethindrone is also a metabolite of the progestagen hormone, Lynestrenol.
References Choudhary, M.I. et al.: Nat. Prod. Res., 24, 1 (2010); Bagocsi, B. et al.: J. Plan. Chrom. Mod. TLC, 16, 359 (2003); Gorog, S. et al.: Chem. Anal., 17, 263 (1972);

Formula: C₂₀H₂₆O₃

Color and Shape: Neat

Molecular weight: 314.419

Ref: TR-H750050

10β-Hydroxy Norethindrone

CAS: 1236-00-6

Formula: C₂₀H₂₆O₃

Molecular weight: 314.43

Ref: ST-EA-CP-N51014