CAS 123658-06-0

Thiorphan Disulfide

Description:

Thiorphan disulfide, identified by its CAS number 123658-06-0, is a chemical compound that features a disulfide bond, which is a linkage between two sulfur atoms. This compound is known for its role as an inhibitor of enkephalinase, an enzyme that breaks down enkephalins, which are peptides involved in pain modulation and other physiological processes. Thiorphan disulfide exhibits characteristics typical of disulfide compounds, including the ability to form covalent bonds with thiol groups in proteins, potentially influencing protein structure and function. It is often studied in the context of pharmacology and biochemistry due to its effects on neuropeptide metabolism. The compound is typically handled with care in laboratory settings, as disulfides can be reactive and may undergo oxidation or reduction reactions. Its applications may extend to research in pain management and neurobiology, although specific therapeutic uses would depend on further studies and regulatory approvals.

Formula: C₂₄H₂₈N₂O₆S₂

Synonyms:

• 2,2'-((3,3'-disulfanediylbis(2-benzylpropanoyl))bis(azanediyl))diacetic acid
• Racecadotril EP Impurity D (Diastereomers)
• Racecadotril Impurity D(Mixture of Diastereomers)
• 5,10-Dibenzyl-4,11-dioxo-7,8-dithia-3,12-diazatetradecanedioic Acid
• Thiorphan Disulfide
• Racecadotril EP Impurity D (Mixture of Diastereomers)
• Racecadotril impurity 3/Racecadotril EP impurity D/5,10-dibenzyl-4,11-dioxo-7,8-dithia-3,12-diazatetradecanedioic acid
• Racecadotril EP Impurity D
• Glycine, N,N'-[dithiobis[1-oxo-2-(phenylmethyl)-3,1-propanediyl]]bis- (9CI)
• Racecadotril Impurity 4（Racecadotril EP Impurity D）

Racecadotril EP Impurity D (Mixture of Diastereomers)

CAS: 123658-06-0

Formula: C₂₄H₂₈N₂O₆S₂

Color and Shape: White To Off-White Solid

Molecular weight: 504.62

Ref: 4Z-R-732

Thiorphan Disulfide

Controlled Product

CAS: 123658-06-0

Applications Thiorphan Disulfide is an impurity of Racecadotril (R070600); an antidiarrheal and enkephalinase inhibitor that reduces the amount of water and electrolytes into the intestine.
References Cezard, J., et al.: Gastroenterol., 120, 799 (2001); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009); Fournie-Zaluski

Formula: C₂₄H₂₈N₂O₆S₂

Color and Shape: Neat

Molecular weight: 504.62

Ref: TR-T369505

Thiorphan disulfide

CAS: 123658-06-0

Thiorphan disulfide is a compound known as an enkephalinase inhibitor, which is derived synthetically for research purposes. Its mode of action involves the inhibition of enkephalinase, an enzyme responsible for the degradation of enkephalins, which are endogenous peptides that modulate pain and emotion. By preventing the breakdown of these peptides, Thiorphan disulfide enhances their activity, resulting in increased analgesic effects.

Formula: C₂₄H₂₈N₂O₆S₂

Purity: Min. 95%

Molecular weight: 504.6 g/mol

Ref: 3D-YEA65806

Racecadotril EP Impurity D

CAS: 123658-06-0

Formula: C₂₄H₂₈N₂O₆S₂

Molecular weight: 504.62

Ref: ST-EA-CP-R21005

Thiorphan disulfide

CAS: 123658-06-0

Thiorphan disulfide: Racecadotril impurity; antidiarrheal; limits water/electrolyte intestinal absorption.

Formula: C₂₄H₂₈N₂O₆S₂

Color and Shape: Solid

Molecular weight: 504.62

Ref: TM-T71161