CAS 123663-49-0

Iguratimod

Description:

Iguratimod is a synthetic small molecule classified as an immunomodulator, primarily used in the treatment of rheumatoid arthritis. Its chemical structure features a unique combination of functional groups that contribute to its pharmacological activity. Iguratimod works by inhibiting the production of pro-inflammatory cytokines and modulating immune responses, which helps to reduce inflammation and joint damage associated with autoimmune conditions. The substance is known for its relatively favorable safety profile compared to traditional disease-modifying antirheumatic drugs (DMARDs). In terms of solubility, Iguratimod is generally soluble in organic solvents but has limited solubility in water, which can affect its bioavailability. The compound is typically administered orally and is metabolized in the liver, with its pharmacokinetics influenced by various factors, including dosage and individual patient characteristics. Overall, Iguratimod represents a valuable option in the therapeutic landscape for managing chronic inflammatory diseases.

Formula: C₁₇H₁₄N₂O₆S

InChI: InChI=1S/C17H14N2O6S/c1-26(22,23)19-13-8-15-12(17(21)14(9-24-15)18-10-20)7-16(13)25-11-5-3-2-4-6-11/h2-10,19H,1H3,(H,18,20)

InChI key: InChIKey=ANMATWQYLIFGOK-UHFFFAOYSA-N

SMILES: O=C1C=2C(=CC(NS(C)(=O)=O)=C(OC3=CC=CC=C3)C2)OC=C1NC=O

Synonyms:

• 3-Formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one
• Ailamode
• Careram
• Kolbet
• Methanesulfonamide, N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-
• N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]methanesulfonamide
• N-[3-(formylamino)-4-oxo-6-phenoxy-4H-chromen-7-yl]methanesulfonamide
• N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide
• T 614
• T 614 (antiinflammatory)
• iguratimod( R&D)

Methanesulfonamide, N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-

CAS: 123663-49-0

Formula: C₁₇H₁₄N₂O₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 374.3679

Ref: IN-DA000KXN

Iguratimod

CAS: 123663-49-0

Iguratimod

Purity: ≥98%

Molecular weight: 374.37g/mol

Ref: 54-BUP06252

N-(7-(Methylsulfonamido)-4-Oxo-6-Phenoxy-4H-Chromen-3-Yl)Formamide

CAS: 123663-49-0

N-(7-(Methylsulfonamido)-4-Oxo-6-Phenoxy-4H-Chromen-3-Yl)Formamide

Purity: 99%

Molecular weight: 374.37g/mol

Ref: 54-OR1014017

Iguratimod

CAS: 123663-49-0

Formula: C₁₇H₁₄N₂O₆S

Color and Shape: White To Off-White Solid

Molecular weight: 374.37

Ref: 4Z-I-092001

Iguratimod

CAS: 123663-49-0

Formula: C₁₇H₁₄N₂O₆S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 374.37

Ref: 3B-I0945

Iguratimod

CAS: 123663-49-0

Iguratimod (T614) is a COX-2 inhibitor (IC50: 20 μM), does not affect COX-1, and inhibits MIF (IC50: 6.81 μM).

Formula: C₁₇H₁₄N₂O₆S

Purity: 99.93%

Color and Shape: White Powder

Molecular weight: 374.37

Ref: TM-T5032

N-(7-(Methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide

CAS: 123663-49-0

Purity: 95.0%

Molecular weight: 374.3699951171875

Ref: 10-F213725

Iguratimod

CAS: 123663-49-0

Positive regulator of NF-κB and RANKL; anti-rheumatic; anti-inflammatory

Formula: C₁₇H₁₄N₂O₆S

Purity: Min. 95%

Color and Shape: White Clear Liquid

Molecular weight: 374.37 g/mol

Ref: 3D-FI39374

Iguratimod - Bio-X ™

CAS: 123663-49-0

Iguratimod is a drug that is used to treat autoimmune and inflammatory conditions such as rheumatoid arthritis. This drug works by suppressing the activity of inflammatory cells and cytokines such as interleukin-1 and tumor necrosis factor-alpha (TNF-alpha). By reducing the levels of these cytokines, Iguratimod helps to alleviate inflammation and joint damage associated with conditions like rheumatoid arthritis.

Formula: C₁₇H₁₄N₂O₆S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 374.37 g/mol

Ref: 3D-BI164569

Iguratimod-d5

Controlled Product

CAS: 123663-49-0

Formula: C₁₇D₅H₉N₂O₆S

Color and Shape: Neat

Molecular weight: 379.399

Ref: TR-I265102

Iguratimod

Controlled Product

CAS: 123663-49-0

Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.
References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);

Formula: C₁₇H₁₄N₂O₆S

Color and Shape: Neat

Molecular weight: 374.37

Ref: TR-I265100