CAS 123714-50-1

Acetyl-Calpastatin (184-210) (human)

Description:

Acetyl-Calpastatin (184-210) is a peptide derived from calpastatin, which is a specific inhibitor of calpain, a calcium-dependent cysteine protease involved in various cellular processes, including apoptosis and muscle development. This peptide corresponds to a specific fragment of the calpastatin protein, with the acetylation at the N-terminus enhancing its stability and bioactivity. The CAS number 123714-50-1 identifies this compound uniquely in chemical databases. Acetyl-Calpastatin (184-210) is primarily studied for its role in regulating calpain activity, which is crucial in muscle physiology and pathology. Its characteristics include a relatively small molecular size typical of peptides, and it is soluble in aqueous solutions, making it suitable for various biochemical assays. The peptide's inhibitory action on calpain has implications in research related to muscle disorders, neurodegenerative diseases, and cellular signaling pathways. Overall, Acetyl-Calpastatin (184-210) serves as a valuable tool in understanding the regulatory mechanisms of proteolysis in biological systems.

Formula: C₁₄₂H₂₃₀N₃₆O₄₄S

Synonyms:

• Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

Acetyl-Calpastatin (184-210) (human)

CAS: 123714-50-1

Acetyl-calpastatin 27 peptide, AC27P, a calpain inhibitor homologous to the minimal inhibitory domain I of human calpastatin, was shown to modulate the amyloid β-protein 42 secretion ratio. This finding might point to the possibility of exploring compounds that inhibit Aβ42 secretion.

Formula: C₁₄₂H₂₃₀N₃₆O₄₄S

Purity: > 95%

Color and Shape: White Lyophilisate

Molecular weight: 3177.67

Ref: 01-4027881

Acetyl-Calpastatin(184-210)(human)

CAS: 123714-50-1

Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.

Formula: C₁₄₂H₂₃₀N₃₆O₄₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 3177.65

Ref: TM-TP2056

Acetyl-Calpastatin (184-210) (human)

CAS: 123714-50-1

Acetyl-Calpastatin (184-210) (human) Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-(184–210) is a protease inhibitor that inhibits the activity of calpain, an enzyme involved in the degradation of proteins. It has been used for the treatment of infectious diseases such as tuberculosis and autoimmune diseases such as multiple sclerosis. Acetylcalpastatin is synthesized from calpastatin, which is found in abundance in the central nervous system and skeletal muscle. Acetylcalpastatin has been shown to inhibit experimental models of the disease by interfering with the production of inflammatory mediators.

Formula: C₁₄₂H₂₃₀N₃₆O₄₄S

Purity: Min. 95%

Molecular weight: 3,177.63 g/mol

Ref: 3D-FA109173