CAS 1238210-10-0

EMtricitabine Carboxylic Acid

Description:

EMtricitabine Carboxylic Acid, with the CAS number 1238210-10-0, is a chemical compound that serves as a metabolite of the antiretroviral drug emtricitabine, which is used in the treatment of HIV. This compound is characterized by its structural features, including a carboxylic acid functional group, which contributes to its solubility and reactivity. EMtricitabine Carboxylic Acid is typically a white to off-white solid, and it is soluble in water due to the presence of polar functional groups. The compound exhibits properties typical of nucleoside analogs, including the ability to inhibit reverse transcriptase, an enzyme critical for viral replication. Its pharmacokinetic profile is influenced by factors such as absorption, distribution, metabolism, and excretion, which are essential for understanding its therapeutic potential and safety. Additionally, the compound is subject to regulatory scrutiny and is often analyzed for purity and potency in pharmaceutical formulations. Overall, EMtricitabine Carboxylic Acid plays a significant role in HIV treatment regimens, contributing to the management of the virus in affected individuals.

Formula: C₈H₈FN₃O₄S

Synonyms:

• Emitricitabine – Impurity RR acid
• EMtricitabine Carboxylic Acid
• Emtricitabine Carboxylic acid impurity
• 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-, (2R,5S)-
• (2R,5S)-Emtricitabine Carboxylic Acid
• Emtricitabine IP Impurity A
• Emtricitabine IP IMP A
• Emtricitabine impurity 11/(2R,5S)-Emtricitabine Carboxylic Acid/(2R,5S)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylic acid
• Emtricitabine IP Impurity A (Emtricitabine Carboxylic Acid)

Emtricitabine Carboxylic Acid ((2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid)

CAS: 1238210-10-0

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₈H₈FN₃O₄S

Color and Shape: White Off-White Solid

Molecular weight: 261.02196

Ref: 45-1A04980

(2R,5S)-Emtricitabine Carboxylic Acid

CAS: 1238210-10-0

Formula: C₈H₈FN₃O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 261.23

Ref: 4Z-E-583

Emtricitabine IP Impurity A

CAS: 1238210-10-0

Formula: C₈H₈FN₃O₄S

Molecular weight: 261.23

Ref: ST-EA-CP-E5004

Emtricitabine Carboxylic Acid

Controlled Product

CAS: 1238210-10-0

Impurity Emtricitabine Carboxylic Acid Impurity
Applications Emtricitabine Carboxylic Acid is an impurity of the antiviral agent Emtricitabine (E525035).
References Pendela, M. et al.: Talanta, 82, 125 (2010);

Formula: C₈H₈FN₃O₄S

Color and Shape: Neat

Molecular weight: 261.23

Ref: TR-E525035

Emtricitabine Carboxylic Acid-13C,15N2

Controlled Product

CAS: 1238210-10-0

Formula: CC₇H₈F₁₅N₂NO₄S

Color and Shape: Neat

Molecular weight: 264.21

Ref: TR-E525037

Emtricitabine carboxylic acid

CAS: 1238210-10-0

Emtricitabine (FTC) is a synthetic nucleoside analog that is approved for the treatment of HIV infection. FTC is metabolized in the liver by cytochrome P450 enzymes into two metabolites, EMTR-diol and EMTR-triol. The pharmacopoeia defines impurity standards for both metabolites. FTC also causes metabolism studies to be conducted to determine its effect on other drugs such as cyclosporin and phenytoin. EMTR-diol: CAS No. 1238210-10-0 EMTR-triol: CAS No. 1238210-11-1

Formula: C₈H₈FN₃O₄S

Purity: Min. 95%

Molecular weight: 261.23 g/mol

Ref: 3D-NZB21010