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CAS 123884-00-4

:

Dolastatin 15

Description:
Dolastatin 15 is a potent peptide derived from the marine mollusk Dolabella auricularia, known for its significant antitumor properties. This compound is characterized by its complex structure, which includes a series of amino acids that contribute to its biological activity. Dolastatin 15 exhibits a unique mechanism of action, primarily by inhibiting microtubule assembly, thereby disrupting the mitotic spindle formation during cell division. This action makes it a candidate for cancer treatment, particularly in targeting various types of tumors. The substance is also noted for its high potency and specificity, which can lead to reduced side effects compared to traditional chemotherapeutic agents. Additionally, Dolastatin 15 has been the subject of extensive research to explore its potential in drug development, although its clinical application is still under investigation. Its stability, solubility, and bioavailability are critical factors that influence its therapeutic efficacy and formulation in pharmaceutical contexts. Overall, Dolastatin 15 represents a promising avenue in the search for effective cancer therapies.
Formula:C45H68N6O9
InChI:InChI=1/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15,18-19,25-29,31-33,36-39H,16-17,20-24H2,1-12H3,(H,46,53)/t31-,32-,33-,36-,37-,38-,39-/m0/s1
SMILES:CC(C)[C@@H](C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc2)C(=CC1=O)OC)N=C([C@H](C(C)C)N(C)C)O
Synonyms:
  • (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
  • (2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl N-methyl-L-valyl-L-prolyl-2-{(2S)-2-[(N,N-dimethyl-L-valyl)amino]-3-methylbutanoyl}-L-prolinate
  • 1-(2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methyl-1-oxobutan-2-yl N,N-dimethylvalylvalyl-N-methylvalylprolylprolinate
  • (1S)-1-{[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]carbonyl}-2-methylpropyl N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinate
  • DOLASTATIN 15
  • L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
  • L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
  • Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
  • (5S)-1-[(2S)-O-(N,N-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE
  • (5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one
  • See more synonyms
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Purity (%)
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100
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0
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50
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90
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95
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100
Found 6 products.