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CAS 123932-43-4

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(R)-Norverapamil

Description:
(R)-Norverapamil is a chiral compound that belongs to the class of calcium channel blockers, primarily used in the treatment of cardiovascular conditions such as hypertension and angina. It is a derivative of verapamil, characterized by its specific stereochemistry, which influences its pharmacological activity and efficacy. The compound exhibits a high affinity for L-type calcium channels, leading to vasodilation and decreased heart rate. In terms of physical properties, (R)-Norverapamil is typically a white to off-white solid, soluble in organic solvents, and has limited solubility in water. Its molecular structure includes a piperidine ring and a phenyl group, contributing to its biological activity. The compound is often studied for its potential therapeutic effects and side effects, as well as its interactions with other medications. As with many pharmaceuticals, the stereochemistry of (R)-Norverapamil is crucial, as the different enantiomers can exhibit varying biological effects. Overall, (R)-Norverapamil represents an important compound in cardiovascular pharmacotherapy.
Formula:C26H36N2O4
InChI:InChI=1S/C26H36N2O4/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5/h8-11,16-17,19,28H,7,12-15H2,1-6H3/t26-/m1/s1
InChI key:InChIKey=UPKQNCPKPOLASS-AREMUKBSSA-N
SMILES:[C@](CCCNCCC1=CC(OC)=C(OC)C=C1)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2
Synonyms:
  • (R)-Norverapamil Hydrochlorid
  • (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Hydrochloride
  • (αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile
  • Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)-ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (aR)-
  • Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (R)-
  • R-Norverapamil
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