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CAS 123948-87-8

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Topotecan

Description:
Topotecan is a chemotherapeutic agent primarily used in the treatment of certain types of cancer, including ovarian cancer and small cell lung cancer. It is classified as a topoisomerase I inhibitor, which means it interferes with the enzyme responsible for DNA replication and repair, ultimately leading to cancer cell death. The chemical structure of Topotecan features a complex ring system and a hydroxyl group, contributing to its biological activity. It is typically administered intravenously, and its pharmacokinetics involve rapid distribution and metabolism, with renal excretion being a significant route for elimination. Common side effects associated with Topotecan include myelosuppression, gastrointestinal disturbances, and fatigue. Due to its mechanism of action, Topotecan is often used in combination with other chemotherapeutic agents to enhance efficacy and overcome resistance. Its development marked a significant advancement in cancer therapy, providing an option for patients with refractory disease. As with all chemotherapeutics, careful monitoring and management of side effects are essential during treatment.
Formula:C23H23N3O5
InChI:InChI=1/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3
InChI key:InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N
SMILES:C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=C(O)C5CN(C)C)COC1=O
Synonyms:
  • (19S)-8-[(Dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
  • (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-Topotecan
  • 10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin
  • 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-[(dimethylamino)methyl]-, hydrochloride, (S)
  • 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-
  • 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-
  • 9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin
  • 9-Dimethylaminomethyl-10-hydroxycamptothecin, HCl salt
  • See more synonyms
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