CAS 123948-87-8: Topotecan

Description: Topotecan is a chemotherapeutic agent primarily used in the treatment of certain types of cancer, including ovarian cancer and small cell lung cancer. It is classified as a topoisomerase I inhibitor, which means it interferes with the enzyme responsible for DNA replication and repair, ultimately leading to cancer cell death. The chemical structure of Topotecan features a complex ring system and a hydroxyl group, contributing to its biological activity. It is typically administered intravenously, and its pharmacokinetics involve rapid distribution and metabolism, with renal excretion being a significant route for elimination. Common side effects associated with Topotecan include myelosuppression, gastrointestinal disturbances, and fatigue. Due to its mechanism of action, Topotecan is often used in combination with other chemotherapeutic agents to enhance efficacy and overcome resistance. Its development marked a significant advancement in cancer therapy, providing an option for patients with refractory disease. As with all chemotherapeutics, careful monitoring and management of side effects are essential during treatment.

Formula: C₂₃H₂₃N₃O₅

InChI: InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1

InChI key: InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N

SMILES: O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=CC(O)=C(C5=CC4C3)CN(C)C

Synonyms:

• (19S)-8-[(Dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (S)-Topotecan
• 10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin
• 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-[(dimethylamino)methyl]-, hydrochloride, (S)
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-
• 9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin
• 9-Dimethylaminomethyl-10-hydroxycamptothecin, HCl salt
• Evotopin
• Hycamptamine
• Hycamptin
• NSC 609699
• Nogitecan
• Potactasol
• Skf 104864
• Skf-S 104864
• TopoCED
• Topophore C
• Topotecan lactone

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-

CAS: 123948-87-8

• Formula: C₂₃H₂₃N₃O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 421.4458199999999

(S)-10-((Dimethylamino)Methyl)-4-Ethyl-4,9-Dihydroxy-1,12-Dihydro-14H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H)-Dione

CAS: 123948-87-8

• Purity: 98%
• Molecular weight: 421.45g/mol

Topotecan hydrochloride hydrate

CAS: 123948-87-8

• Formula: C₂₃H₂₃N₃O₅
• Molecular weight: 421.45

Topotecan

CAS: 123948-87-8

• Purity: 98%
• Molecular weight: 421.45g/mol

Topotecan

CAS: 123948-87-8

• Formula: C₂₃H₂₃N₃O₅
• Color and Shape: Yellow Solid
• Molecular weight: 421.45

Topotecan

CAS: 123948-87-8

• Formula: C₂₃H₂₃N₃O₅·xHCl·yH₂O
• Purity: ≥ 97%
• Color and Shape: Off-white to yellow powder or solid
• Molecular weight: 421.45 (anhydrous)

Topotecan

CAS: 123948-87-8

• Formula: C₂₃H₂₃N₃O₅
• Purity: 95%~99%
• Molecular weight: 421.453

Topotecan

CAS: 123948-87-8

Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian …

• Formula: C₂₃H₂₃N₃O₅
• Purity: 95.19% - 97.58%
• Color and Shape: Light Yellow Needle Crystal Or Crystalline Powder
• Molecular weight: 421.45

Topotecan

CAS: 123948-87-8

Topoisomerase I inhibitor; HIF-1 inhibitor

• Formula: C₂₃H₂₃N₃O₅
• Purity: Min. 95%
• Molecular weight: 421.45 g/mol