CAS 124001-41-8

ICI 216,140

Description:

ICI 216,140, also known by its CAS number 124001-41-8, is a synthetic compound that belongs to the class of selective estrogen receptor modulators (SERMs). It is primarily characterized by its ability to selectively bind to estrogen receptors, exhibiting estrogenic activity in certain tissues while acting as an antagonist in others. This dual action makes it a subject of interest in research related to hormone-related conditions, particularly in the context of breast cancer treatment and osteoporosis management. ICI 216,140 is known for its potential to modulate estrogenic effects, which can lead to beneficial outcomes in specific medical scenarios. Additionally, it has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, which are crucial for understanding its therapeutic applications and safety profile. As with many chemical substances, handling and usage require adherence to safety protocols due to potential biological effects. Overall, ICI 216,140 represents a significant area of study in medicinal chemistry and endocrinology.

Formula: C₄₅H₆₅N₁₃O₈

InChI: InChI=1/C45H65N13O8/c1-23(2)14-33(46-9)41(62)58-44(65)36(17-30-20-48-22-51-30)55-39(60)26(7)53-45(66)37(24(3)4)57-40(61)27(8)52-42(63)34(15-28-18-49-32-13-11-10-12-31(28)32)56-43(64)35(54-38(59)25(5)6)16-29-19-47-21-50-29/h10-13,18-27,33-37,46,49H,14-17H2,1-9H3,(H,47,50)(H,48,51)(H,52,63)(H,53,66)(H,54,59)(H,55,60)(H,56,64)(H,57,61)(H,58,62,65)/t26-,27+,33+,34+,35+,36+,37+/m1/s1

Synonyms:

• (Ch3)2Chco-His-Trp-Ala-Val-D-Ala-His-Leu-Nhch3
• Ici 216,140 Synthetic >95% Potent In Viv O Antago
• N-(2-methylpropanoyl)-L-histidyl-L-tryptophyl-L-alanyl-L-valyl-D-alanyl-N-[(2S)-4-methyl-2-(methylamino)pentanoyl]-L-histidinamide

Ici 216140

CAS: 124001-41-8

ICI 216140: GRP/bombesin receptor 2 blocker, potent at 2 nM. Reduces amylase at 2 mg/kg and lowers bombesin-induced blood pressure at 1 mM in rats.

Formula: C₄₅H₆₅N₁₃O₈

Color and Shape: Solid

Molecular weight: 916.08

Ref: TM-T25522