CAS 124012-42-6

Galocitabine

Description:

Galocitabine, with the CAS number 124012-42-6, is a synthetic nucleoside analog that exhibits properties characteristic of both antiviral and antitumor agents. It is structurally related to cytidine and functions primarily as an inhibitor of DNA synthesis. Galocitabine is known for its ability to interfere with the replication of DNA in rapidly dividing cells, making it a candidate for cancer treatment. Its mechanism of action involves incorporation into the DNA strand, leading to chain termination and ultimately cell death. The compound has shown activity against various types of cancer, particularly in preclinical studies. Additionally, Galocitabine may exhibit some selectivity for certain tumor types, which is an important consideration in therapeutic applications. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its efficacy and safety profile in clinical settings. Overall, Galocitabine represents a promising avenue in the development of targeted cancer therapies, although further research is necessary to fully elucidate its potential benefits and limitations.

Formula: C₁₉H₂₂FN₃O₈

InChI: InChI=1S/C19H22FN3O8/c1-8-13(24)14(25)18(31-8)23-7-10(20)16(22-19(23)27)21-17(26)9-5-11(28-2)15(30-4)12(6-9)29-3/h5-8,13-14,18,24-25H,1-4H3,(H,21,22,26,27)/t8-,13-,14-,18-/m1/s1

InChI key: InChIKey=TVYPSLDUBVTDIS-FUOMVGGVSA-N

SMILES: O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)N=C(NC(=O)C3=CC(OC)=C(OC)C(OC)=C3)C(F)=C2

Synonyms:

• 5'-Deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)cytidine
• 5′-Deoxy-5-fluoro-N⁴-(3,4,5-trimethoxybenzoyl)cytidine
• Cytidine, 5'-deoxy-5-fluoro-N-(3,4,5-trimethoxybenzoyl)-
• Galocitabina
• Galocitabina [INN-Spanish]
• Galocitabine [INN]
• Galocitabinum
• Galocitabinum [INN-Latin]
• N-(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-3,4,5-trimethoxybenzamide
• Ro 09-1390
• Unii-X9788Xi79O
• 5′-Deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine

Galocitabine

CAS: 124012-42-6

Galocitabine

Purity: ≥98%

Molecular weight: 439.39g/mol

Ref: 54-BUP12326

Galocitabine

CAS: 124012-42-6

Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.

Formula: C₁₉H₂₂FN₃O₈

Purity: 99.89%

Color and Shape: Solid

Molecular weight: 439.39

Ref: TM-T27399