CAS 124050-77-7

dioctadecylamidoglycylspermine

Description:

Dioctadecylamidoglycylspermine is a synthetic compound that belongs to the class of polyamines, specifically a derivative of spermine. It is characterized by its long hydrocarbon chains, which contribute to its amphiphilic nature, allowing it to interact with both hydrophilic and hydrophobic environments. This compound is often studied for its potential applications in drug delivery systems, particularly in enhancing the cellular uptake of therapeutic agents due to its ability to form complexes with nucleic acids. Its structure includes two octadecyl chains, which provide significant lipophilicity, and a glycine moiety that can facilitate interactions with biological membranes. The presence of the spermine backbone may also impart biological activity, making it of interest in various biochemical and pharmaceutical research areas. Additionally, dioctadecylamidoglycylspermine has been investigated for its role in gene therapy and as a potential vector for delivering genetic material into cells. Overall, its unique structural features make it a valuable compound in the field of medicinal chemistry and nanotechnology.

Formula: C₄₉H₁₀₂N₆O₂

InChI: InChI=1/C49H102N6O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-44-55(45-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)46-48(56)54-49(57)47(53-43-37-40-51)38-35-41-52-42-36-39-50/h47,52-53H,3-46,50-51H2,1-2H3,(H,54,56,57)/t47-/m0/s1

Synonyms:

• Dioctadecylamidoglycylspermine
• 1-Dogs
• N~2~,N~5~-bis(3-aminopropyl)-N-[(dioctadecylamino)acetyl]-L-ornithinamide
• Transfectam
• Glycinamide, N2,N5-bis(3-aminopropyl)-L-ornithyl-N,N-dioctadecyl-

Transfectam

CAS: 124050-77-7

Transfectam, a cationic lipid, forms complexes with DNA, facilitating efficient gene transfer into a range of eukaryotic cells [1].

Formula: C₄₉H₁₀₂N₆O₂

Color and Shape: Solid

Molecular weight: 807.37

Ref: TM-T74246