CAS 124083-20-1

Etomoxir

Description:

Etomoxir is a synthetic compound primarily known for its role as an inhibitor of carnitine palmitoyltransferase I (CPT I), an enzyme involved in the transport of long-chain fatty acids into the mitochondria for beta-oxidation. This inhibition leads to a decrease in fatty acid oxidation and an increase in glucose oxidation, making it of interest in metabolic research and potential therapeutic applications for conditions like obesity and type 2 diabetes. Chemically, Etomoxir is characterized by its unique structure, which includes a thiazolidine ring and a long hydrophobic tail, contributing to its lipophilicity. It is typically administered in research settings rather than as a clinical drug, and its effects on metabolism have been studied in various animal models. Safety and toxicity profiles are important considerations, as with any pharmacological agent, and ongoing research continues to explore its mechanisms and potential applications in metabolic disorders.

Formula: C₁₇H₂₃ClO₄

InChI: InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m1/s1

InChI key: InChIKey=DZLOHEOHWICNIL-QGZVFWFLSA-N

SMILES: C(OCC)(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1

Synonyms:

• (R)-(+)-Etomoxir
• (R)-Ethyl 2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate
• 2-Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-
• Ethyl (+)-(R)-2-(6-(p-chlorophenoxy)hexyl)glycidate
• Etomoxir [INN]
• Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2R)-
• Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (R)-
• Unii-Msb3Dd2Xp6
• ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate
• ethyl (2S)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate
• Etomoxir

R-(+)-Etomoxir

CAS: 124083-20-1

Formula: C₁₇H₂₃ClO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 326.8151

Ref: IN-DA009CBM

Etomoxir

CAS: 124083-20-1

Etomoxir

Purity: ≥98%

Molecular weight: 326.82g/mol

Ref: 54-BUP12885

Etomoxir-d5

CAS: 124083-20-1

Formula: C₁₇H₁₈D₅ClO₄

Molecular weight: 331.85

Ref: 4Z-E-232002

Etomoxir

CAS: 124083-20-1

Formula: C₁₇H₂₃ClO₄

Molecular weight: 326.82

Ref: 4Z-E-232001

Etomoxir-13C6

CAS: 124083-20-1

Formula: C₁₁₁₃C₆H₂₃ClO₄

Molecular weight: 332.77

Ref: 4Z-E-232003

2-OXIRANECARBOXYLIC ACID, 2-[6-(4-CHLOROPHENOXY)HEXYL]-, ETHYL ESTER, (2R)-

CAS: 124083-20-1

Purity: 98%

Molecular weight: 326.8200073

Ref: 10-F835733

R-(+)-Etomoxir

Controlled Product

CAS: 124083-20-1

Applications An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Crilley, M.M.L., et al.: Tetrahedron Letters, 30, 7, 885 (1989),

Formula: C₁₇H₂₃ClO₄

Color and Shape: Neat

Molecular weight: 326.82

Ref: TR-E933505

Etomoxir

CAS: 124083-20-1

Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a) (IC50=5-20 nM), inhibits fatty acid oxidation. High-Quality, Low-Cost!

Formula: C₁₇H₂₃ClO₄

Purity: 98% - 99.39%

Color and Shape: Solid

Molecular weight: 326.82

Ref: TM-T4535L