CAS 124123-15-5

Pituitary Adenylate Cyclase Activating Polypeptide (1-38) amide (human, ovine, rat)

Description:

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) is a neuropeptide that plays a crucial role in various physiological processes, including neuroprotection, neurotransmission, and hormone secretion. The specific form known as PACAP (1-38) amide refers to a 38-amino acid peptide that is amidated at its C-terminus, enhancing its stability and biological activity. This peptide is highly conserved across species, including humans, sheep (ovine), and rats, indicating its fundamental biological importance. PACAP exerts its effects primarily through binding to specific receptors, leading to the activation of adenylate cyclase and subsequent increases in intracellular cyclic AMP levels. It is involved in numerous functions, such as regulating circadian rhythms, modulating stress responses, and influencing reproductive functions. Additionally, PACAP has been implicated in various pathological conditions, including neurodegenerative diseases and mood disorders, making it a subject of interest in both basic and clinical research. Its CAS number, 124123-15-5, is a unique identifier used for regulatory and research purposes, facilitating the tracking and study of this peptide in scientific literature.

Formula: C₂₀₃H₃₃₁N₆₃O₅₃S

Synonyms:

• H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2

PACAP-38 (human, mouse, ovine, porcine, rat)

CAS: 124123-15-5

Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.

Formula: C₂₀₃H₃₃₁N₆₃O₅₃S

Purity: 97.6%

Color and Shape: White

Molecular weight: 4534.32

Ref: 01-4031157

PACAP38 (Human)

CAS: 124123-15-5

PACAP38 is a ligand that belongs to the family of peptides. It binds to the PAC1 receptor and activates it. PACAP38 has been shown to inhibit ion channels, such as potassium channels and calcium channels, in neuronal cells. The protein interactions of PACAP38 are not yet fully understood.

Formula: C₂₀₃H₃₃₁N₆₃O₅₃S

Purity: Min. 95%

Molecular weight: 4,534.3 g/mol

Ref: 3D-PPA-4221-V

PACAP-38 (human, mouse, ovine, porcine, rat) trifluoroacetate salt

CAS: 124123-15-5

PACAP-38 is a peptide that has been shown to have a variety of physiological effects, including the regulation of brain functions and immunological responses. PACAP-38 has been found to bind to toll-like receptor 4 (TLR4) in macrophages and neutrophils, which stimulates the production of proinflammatory cytokines. It also interacts with adenylate cyclase, which leads to an increase in cAMP levels. This may be the mechanism by which PACAP-38 regulates brain functions. The biological function of PACAP-38 is not yet clear but it may act as a signal peptide, regulating protein synthesis and gene expression.

Formula: C₂₀₃H₃₃₁N₆₃O₅₃S

Purity: Min. 95%

Molecular weight: 4,534.26 g/mol

Ref: 3D-FP110313