CAS 1241902-40-8

GNE-0439

CAS: 1241902-40-8

GNE-0439 is a small molecule that inhibits the activity of the sodium channel. It binds to the extracellular domain of the alpha subunit and blocks voltage-gated sodium channels, which are necessary for action potential propagation. GNE-0439 is a potent inhibitor of neuronal and cardiomyocyte Na(+) current, with an IC50of 2 nM in rat neurons and 1 μM in human atrial myocytes. In addition, GNE-0439 inhibits voltage-gated potassium channels (IC50 = 200 nM) and glutamate receptors (IC50 = 2 μM).
GNE-0439 is a high purity compound that has been synthesized according to Good Manufacturing Practices (GMP). It is >98% pure as determined by HPLC analysis.

Formula: C₂₁H₃₁NO₃

Purity: Min. 95%

Molecular weight: 345.5 g/mol

Ref: 3D-RZB90240

GNE-0439

CAS: 1241902-40-8

GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.

Formula: C₂₁H₃₁NO₃

Purity: 99.60%

Color and Shape: Solid

Molecular weight: 345.48

Ref: TM-T11437