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CAS 1242137-16-1

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N-Desmethylenzalutamide

Description:
N-Desmethylenzalutamide is a chemical compound that serves as a metabolite of the anti-androgen drug enzalutamide, which is primarily used in the treatment of prostate cancer. This substance is characterized by its structural modifications that result from the removal of a methylene group from the enzalutamide molecule. N-Desmethylenzalutamide exhibits similar pharmacological properties to its parent compound, including the ability to inhibit androgen receptor signaling, which is crucial in the progression of prostate cancer. The compound is typically studied for its role in drug metabolism and pharmacokinetics, as well as its potential therapeutic implications. In terms of physical properties, N-Desmethylenzalutamide is expected to be a solid at room temperature, with specific solubility characteristics that may influence its bioavailability. Its safety profile and efficacy are subjects of ongoing research, particularly in understanding how it contributes to the overall therapeutic effects of enzalutamide and its potential resistance mechanisms in cancer treatment.
Formula:C20H14F4N4O2S
InChI:InChI=1S/C20H14F4N4O2S/c1-19(2)17(30)27(11-4-3-10(9-25)14(7-11)20(22,23)24)18(31)28(19)12-5-6-13(16(26)29)15(21)8-12/h3-8H,1-2H3,(H2,26,29)
InChI key:InChIKey=JSFOGZGIBIQRPU-UHFFFAOYSA-N
SMILES:S=C1N(C(C)(C)C(=O)N1C2=CC(C(F)(F)F)=C(C#N)C=C2)C3=CC(F)=C(C(N)=O)C=C3
Synonyms:
  • N-Desmethylenzalutamide
  • Benzamide, 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-
  • 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzamide
  • Enzalutamide Impurity R
  • CS-1325
  • N-DESMETHYL MDV3100;N-DESMETHYL MDV 3100;N-DESMETHYL MDV-3100
  • Enzalutamide Impurity 2
  • N-desMethyl EnzalutaMide
  • Enzalutamide impurity B
  • N-desmethyl MDV-3100
  • See more synonyms
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