CAS 124351-85-5

Incadronic acid

Description:

Incadronic acid is a chemical compound classified as a bisphosphonate, primarily used in the treatment of bone-related conditions, particularly osteoporosis. Its structure features two phosphonate groups, which contribute to its ability to inhibit bone resorption by osteoclasts, thereby enhancing bone density. Incadronic acid is known for its relatively long half-life, allowing for less frequent dosing compared to other bisphosphonates. The compound exhibits high affinity for hydroxyapatite, a mineral component of bone, facilitating its localization in bone tissue. Additionally, it has been studied for its potential effects on mineral metabolism and its role in reducing the risk of fractures. As with other bisphosphonates, common side effects may include gastrointestinal disturbances and potential renal toxicity, necessitating careful monitoring during treatment. Overall, incadronic acid represents a significant advancement in the management of osteoporosis and related disorders, contributing to improved patient outcomes in bone health.

Formula: C₈H₁₉NO₆P₂

InChI: InChI=1S/C8H19NO6P2/c10-16(11,12)8(17(13,14)15)9-7-5-3-1-2-4-6-7/h7-9H,1-6H2,(H2,10,11,12)(H2,13,14,15)

InChI key: InChIKey=LWRDQHOZTAOILO-UHFFFAOYSA-N

SMILES: C(NC1CCCCCC1)(P(=O)(O)O)P(=O)(O)O

Synonyms:

• ((Cycloheptylamino)methylene)diphosphonic acid
• Cimadronate
• Cimadronic acid
• Icandronate
• Incadronic acid
• Incadronic acid [INN]
• P,P′-[(Cycloheptylamino)methylene]bis[phosphonic acid]
• Phosphonic acid, P,P′-[(cycloheptylamino)methylene]bis-
• Phosphonic acid, [(cycloheptylamino)methylene]bis-
• Unii-G5C4M8847E
• [(Cycloheptylamino)Methanediyl]Bis(Phosphonic Acid)

Incandronate

CAS: 124351-85-5

Formula: C₈H₁₉NO₆P₂

Color and Shape: Solid

Molecular weight: 287.1871

Ref: IN-DA000LXG

Incandronate

CAS: 124351-85-5

Applications Incandronate is a bisphosphonate derivative. Bisphosphonates are most widely used as agents for treating osteoporosis and have also been used for other purposes such as herbicides, anticancer agents, and antiparasitics.
References Xie, A., et al.: Internet Electron J. Mol. Des., 3, 622 (2004)

Formula: C₈H₁₉NO₆P₂

Color and Shape: White To Off-White

Molecular weight: 287.19

Ref: TR-I499700

Incadronic acid

CAS: 124351-85-5

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Formula: C₈H₁₉NO₆P₂

Purity: Min. 95%

Molecular weight: 287.19 g/mol

Ref: 3D-ZEA35185