V-ATPase-IN-1, identified by its CAS number 1243603-61-3, is a small molecule inhibitor specifically targeting the vacuolar-type H+-ATPase (V-ATPase) enzyme. This enzyme plays a crucial role in various cellular processes, including pH regulation, nutrient transport, and cellular homeostasis. V-ATPase-IN-1 is characterized by its ability to selectively inhibit V-ATPase activity, which can lead to alterations in cellular acidification and impact processes such as autophagy and tumor progression. The compound is of interest in research related to cancer therapy, as V-ATPase inhibition has been linked to reduced tumor growth and metastasis. Additionally, V-ATPase-IN-1 may exhibit potential effects on immune responses and other physiological processes. Its chemical structure and properties facilitate its interaction with the V-ATPase complex, making it a valuable tool for studying the enzyme's function and its implications in various diseases. As with any chemical substance, safety and handling precautions should be observed when working with V-ATPase-IN-1 in laboratory settings.

V-ATPase-IN-1

1243603-61-3: V-ATPase-IN-1, identified by its CAS number 1243603-61-3, is a small molecule inhibitor specifically targeting the vacuolar-type H+-ATPase (V-ATPase) enzyme. This enzyme plays a crucial role in various cellular processes, including pH regulation, nutrient transport, and cellular homeostasis. V-ATPase-IN-1 is characterized by its ability to selectively inhibit V-ATPase activity, which can lead to alterations in cellular acidification and impact processes such as autophagy and tumor progression. The compound is of interest in research related to cancer therapy, as V-ATPase inhibition has been linked to reduced tumor growth and metastasis. Additionally, V-ATPase-IN-1 may exhibit potential effects on immune responses and other physiological processes. Its chemical structure and properties facilitate its interaction with the V-ATPase complex, making it a valuable tool for studying the enzyme's function and its implications in various diseases. As with any chemical substance, safety and handling precautions should be observed when working with V-ATPase-IN-1 in laboratory settings.

<p>V-ATPase-IN-1 (Compound 3b-03) is an inhibitor of Vacuolar-type H+-ATPases (V-ATPase), exhibiting an inhibition constant (IC50) of 194.80 μM and effectively targeting the V-ATPase subunit A with a dissociation constant (Kd) of 0.803 μM. This compound demonstrates insecticidal activity against M. separata (LC50 = 2.64 mM), aiding in the development of chemical insecticides.</p>

CAS 1243603-61-3

V-ATPase-IN-1

V-ATPase-IN-1

Ref: TM-T200467