CAS 124363-98-0

Endothelin-1 (ET-1) is a potent vasoconstrictor peptide that plays a crucial role in various physiological and pathological processes, particularly in the cardiovascular system. It is produced primarily by endothelial cells and is involved in regulating vascular tone, blood pressure, and fluid balance. The "big" form of endothelin-1 refers to its precursor, big endothelin-1, which is a larger, inactive form that is converted into the active peptide through enzymatic cleavage. This precursor has a higher molecular weight and is typically found in circulation before being processed into the active form. Endothelin-1 exerts its effects by binding to specific receptors, ET_A and ET_B, which are distributed throughout various tissues, including blood vessels and the heart. Dysregulation of endothelin-1 levels has been implicated in several cardiovascular diseases, including hypertension and heart failure. Additionally, it has roles in cell proliferation and inflammation, making it a significant target for therapeutic interventions in related conditions.