CAS 124412-58-4

16-hydroxyclarithromycin

Description:

16-Hydroxyclarithromycin is a semi-synthetic derivative of the macrolide antibiotic clarithromycin, which is derived from erythromycin. This compound is characterized by the presence of a hydroxyl group at the 16th carbon position of the macrolide ring, which alters its pharmacological properties compared to its parent compound. It exhibits antibacterial activity against a range of Gram-positive and some Gram-negative bacteria, making it useful in treating various infections. The presence of the hydroxyl group enhances its solubility and may influence its bioavailability and metabolic stability. Like other macrolides, 16-hydroxyclarithromycin works by inhibiting bacterial protein synthesis, specifically by binding to the 50S ribosomal subunit. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, can vary based on the formulation and route of administration. As with other antibiotics, it is essential to use 16-hydroxyclarithromycin judiciously to prevent the development of antibiotic resistance.

Formula: C₃₈H₆₉NO₁₄

InChI: InChI=1/C38H69NO14/c1-14-26-38(9,46)30(43)22(5)27(41)19(2)16-37(8,48-13)32(53-34-28(42)25(39(10)11)15-20(3)49-34)23(6)29(24(18-40)33(45)51-26)52-35-31(44)36(7,47-12)17-21(4)50-35/h19-26,28-32,34-35,40,42-44,46H,14-18H2,1-13H3

SMILES: CCC1C(C)(C(C(C)C(=O)C(C)CC(C)(C(C(C)C(C(CO)C(=O)O1)OC1C(C(C)(CC(C)O1)OC)O)OC1C(C(CC(C)O1)N(C)C)O)OC)O)O

Synonyms:

• 16-OH-Clr
• 6-{[4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-[(3-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy]-3-(hydroxymethyl)-7-methoxy-5,7,9,11,13-pentamethyloxacyclotetradecane-2,10-dione (non-preferred name)
• 16-Hydroxyclarithromycin

Clarithromycin EP Impurity A

CAS: 124412-58-4

Formula: C₃₈H₆₉NO₁₄

Molecular weight: 763.95

Ref: ST-EA-CP-C1001

Clarithromycin EP Impurity A

CAS: 124412-58-4

Clarithromycin EP Impurity A is an analytical standard for clarithromycin. Clarithromycin EP Impurity A is a white to off-white powder that is soluble in methanol, acetone, and chloroform. It has a molecular weight of 459.23 Da and the chemical formula C18H26N2O5S. Clarithromycin EP Impurity A is an impurity found in clarithromycin that has been isolated from the product by high-performance liquid chromatography (HPLC) and confirmed by nuclear magnetic resonance spectroscopy (NMR). Clarithromycin EP Impurity A can be used as a reference standard for pharmacopoeia testing or as a research and development sample for drug development. It can also be synthesized from natural or synthetic sources.

Formula: C₃₈H₆₉NO₁₄

Purity: 90%Nmr

Color and Shape: Powder

Molecular weight: 763.95 g/mol

Ref: 3D-FC166203

Clarithromycin EP Impurity A (Clarithromycin F)

CAS: 124412-58-4

Formula: C₃₈H₆₉NO₁₄

Molecular weight: 763.97

Ref: 4Z-C-3718